The diagnosis of chlamydia, gonorrhoea, and trichomonas infections by self obtained low vaginal swabs, in remote northern Australian clinical practice
The diagnosis of chlamydia, gonorrhoea, and trichomonas infections by self obtained low vaginal swabs, in remote northern Australian clinical practice
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DOI：
10.1136/sti.78.4.278
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发表时间：
2002-08-01
影响因子：
3.6
通讯作者：
Harnett, GB
中科院分区：
文献类型：
--
作者：
Garrow, SC;Smith, DW;Harnett, GB
目的：在澳大利亚西北部偏远地区的各种临床实践环境中，研究自制低阴道拭子（SOLVS）和聚合酶链反应（PCR）技术在诊断沙眼衣原体（CT）、淋病奈瑟菌（NG）和阴道毛滴虫（TV）感染中的诊断性能。设计：一项由10名以上不同类型的医生在偏远地区进行妇科调查的妇女中进行微生物收集技术的横断面现场研究参与者和设置：来自西澳大利亚西北部金伯利地区偏远城镇和社区的349名妇女，她们因临床原因进行妇科检查、健康妇女筛查、产前筛查和性健康检查。基于任何阳性常规样本，研究人群中CT、NG和TV的总体感染率分别为9.2%、7.6%和16.1%。SOLVS对CT和NG的检出率分别为89%和96%，而宫颈拭子的检出率为79%和91%，首次排尿的检出率为79%和83%。SOLVS检测TV的灵敏度为93%，与临床获得的低阴道拭子的灵敏度相当。这些差异均未达到统计学显著性。SOLVS和第一次排尿检测96%的CT病例，100%的NG病例，和96%的TV cases.Conclusions：自我获得的低阴道拭子是一个可以接受的，简单和敏感的诊断样本的检测CT，NG，和TV，并在远程临床实践中有特殊的应用，并作为一种筛选技术。
Objective: To examine the diagnostic performance of self obtained low vaginal swabs (SOLVS) and polymerase chain reaction (PCR) techniques in the diagnosis of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infection in a variety of clinical practice settings in remote north western Australia.Design: A cross sectional field study of microbiological collection techniques in women undergoing gynaecological investigation in remote settings performed by a variety of practitioner types over 10 months.Participants and setting: 349 women from remote towns and communities in the Kimberley region of north west Western Australia having gynaecological examinations for clinical reasons, well women screening, antenatal screening, and sexual health examinations.Results: The overall prevalence of infection in the study population based on any positive conventional sample was 9.2%, 7.6%, and 16.1% for CT, NG, and TV respectively. The detection rates for CT and NG by SOLVS were 89% and 96% respectively, compared with 79% and 91% for endocervical swabs and 79% and 83% for first void urine. SOLVS had a sensitivity of 93% for TV detection, equal to that of clinician obtained low vaginal swabs. None of these differences reached statistical significance. A combination of SOLVS and first void urine detected 96% of the CT cases, 100% of the NG cases, and 96% of TV cases.Conclusions: Self obtained low vaginal swabs are an acceptable, simple and sensitive diagnostic sample for the detection of CT, NG, and TV, and have particular applications in remote clinical practice and as a screening technique.