Monocyte activation in systemic Covid-19 infection: Assay and rationale
Monocyte activation in systemic Covid-19 infection: Assay and rationale
复制标题
系统性Covid-19感染中的单核细胞活化：测定和原理
DOI：
10.1016/j.ebiom.2020.102964
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发表时间：
2020-09-01
期刊：
影响因子：
11.1
通讯作者：
Gordon, Siamon
中科院分区：
文献类型：
--
作者：
Martinez, Fernando O.;Combes, Theo W.;Gordon, Siamon
单核细胞吞噬细胞是一个广泛分布的细胞家族，有助于先天性和适应性免疫。循环单核细胞和组织巨噬细胞参与SARS COVID-19的所有阶段。它们有助于诱发临床感染、病毒耐药性和传播的共病，以及决定疾病严重程度、恢复和后遗症的宿主因素。检测病毒感染和抗体反应的试验是可用的，但没有足够的测试已经开发来测量单核细胞和组织巨噬细胞的活化水平，以及发展为致命的炎症过度综合征的风险。血液单核细胞提供了全身免疫反应的窗口，从生产到组织招募，反映了感染对宿主的影响。血液的随时可用性使得可以通过开发测试来评估单核细胞激活的状态及其在募集到组织后和恢复期间进一步炎症失调的可能性，从而监测潜在致命并发症的严重性和风险。(C)2020年，任作家。由爱思唯尔公司出版
Mononuclear phagocytes are a widely distributed family of cells contributing to innate and adaptive immunity. Circulating monocytes and tissue macrophages participate in all stages of SARS COVID-19. They contribute to comorbidities predisposing to clinical infection, virus resistance and dissemination, and to host factors that determine disease severity, recovery and sequelae. Assays are available to detect viral infection and antibody responses, but no adequate tests have been developed to measure the activation level of monocytes and tissue macrophages, and the risk of progression to a fatal hyperinflammatory syndrome. Blood monocytes provide a window on the systemic immune response, from production to tissue recruitment, reflecting the impact of infection on the host. Ready availability of blood makes it possible to monitor severity and the risk of potentially lethal complications, by developing tests to assess the status of monocyte activation and its potential for further inflammatory dysregulation after recruitment to tissues and during recovery. (C) 2020 The Authors. Published by Elsevier B.V.