COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.
COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making.
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DOI：
10.1038/srep00677
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发表时间：
2012
影响因子：
4.6
通讯作者：
Bechara, Antoine
中科院分区：
文献类型：
--
作者：
He, Qinghua;Xue, Gui;Chen, Chuansheng;Lu, Zhong-Lin;Chen, Chunhui;Lei, Xuemei;Liu, Yuyun;Li, Jin;Zhu, Bi;Moyzis, Robert K.;Dong, Qi;Bechara, Antoine
遗传和环境因素都被证明会影响决策，但它们的相对贡献和相互作用还没有得到很好的理解。本研究的目的是揭示可能的基因-环境相互作用的决策在一个大的健康样本。具体来说，我们检查了经常研究的COMT Val 158 Met多态性如何与环境风险因素（即，压力性生活事件）和保护性因素（即，父母的温暖），以影响情感的决策所衡量的爱荷华州赌博任务。我们发现压力性生活事件是IGT表现不佳的风险因素（即，高奖励敏感性），而父母的温暖作为良好IGT表现的保护因素（即，瓦尔/瓦尔纯合子中IGT评分较高。这些结果揭示了决策过程中基因-环境相互作用的一些新观点，这可能有助于我们了解与决策障碍相关的几种精神疾病的潜在病因。
Both genetic and environmental factors have been shown to influence decision making, but their relative contributions and interactions are not well understood. The present study aimed to reveal possible gene-environment interactions on decision making in a large healthy sample. Specifically, we examined how the frequently studied COMT Val158Met polymorphism interacted with an environmental risk factor (i.e., stressful life events) and a protective factor (i.e., parental warmth) to influence affective decision making as measured by the Iowa Gambling Task. We found that stressful life events acted as a risk factor for poor IGT performance (i.e., high reward sensitivity) among Met carriers, whereas parental warmth acted as a protective factor for good IGT performance (i.e., higher IGT score) among Val/Val homozygotes. These results shed some new light on gene-environment interactions in decision making, which could potentially help us understand the underlying etiology of several psychiatric disorders associated with decision making impairment.
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影响因子：
3.7
作者：
Bechara, A;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
1.1
作者：
Bechara, A;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
56.9
作者：
BECHARA, A;TRANEL, D;DAMASIO, AR
通讯作者：
DAMASIO, AR
影响因子：
13.7
作者：
Cesarini, David;Dawes, Christopher T.;Wallace, Bjoern
通讯作者：
Wallace, Bjoern
影响因子：
2.6
作者：
Clark, L;Manes, F;Robbins, TW
通讯作者：
Robbins, TW