Usefulness of Blunted Heart Rate Reserve as an Imaging-Independent Prognostic Predictor During Dipyridamole Stress Echocardiography
Usefulness of Blunted Heart Rate Reserve as an Imaging-Independent Prognostic Predictor During Dipyridamole Stress Echocardiography
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DOI：
10.1016/j.amjcard.2019.06.017
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发表时间：
2019-09-15
影响因子：
2.8
通讯作者：
Picano, Eugenio
中科院分区：
文献类型：
--
作者：
Cortigiani, Lauro;Carpeggiani, Clara;Picano, Eugenio
双嘧达莫心肌灌注成像期间心率（HR）反应迟钝与不良结果相关。为了评估接受高剂量双嘧达莫负荷超声心动图 (SE) 的患者 HR 反应的价值，我们回顾性地选择了 3,059 名患者样本（没有起搏器或心房颤动；平均年龄 66 +/- 11 岁）。所有患者均在比萨-IFC 和卢卡的 2 个实验室接受了高剂量（0.84 mg/kg）双嘧达莫 SE 评估已知或疑似冠状动脉疾病和/或心力衰竭。每分钟获得 HR（12 导联心电图）并在休息和峰值压力时记录。心率储备 (HRR) 计算为峰值/休息心率比。所有患者均接受随访。患者被随机分为同等规模的建模组和验证组。在中位随访 1,004 天期间，发生了 321 起严重事件：231 例死亡和 90 例非致命性心肌梗塞。 HRR
A blunted heart rate (HR) response during dipyridamole myocardial perfusion imaging has been associated with a poor outcome. To assess the value of HR response in patients who underwent high-dose dipyridamole stress echocardiography (SE), we retrospectively selected a sample of 3,059 patients (none with pacemakers or atrial fibrillation; mean age 66 +/- 11 years). All underwent high-dose (0.84 mg/kg) dipyridamole SE for evaluation of known or suspected coronary artery disease and/or heart failure in 2 laboratories of Pisa-IFC and Lucca. HR (with 12-lead ECG) was obtained each minute and recorded at rest and peak stress. HR reserve (HRR) was calculated as the peak/rest HR ratio. All patients were followed up. Patients were randomly divided into the modeling and validation group of equal size. During a median follow-up time of 1,004 days, 321 hard events occurred: 231 deaths and 90 nonfatal myocardial infarctions. HRR