Differential Resting State Connectivity Patterns and Impaired Semantically Cued List Learning Test Performance in Early Course Remitted Major Depressive Disorder.
Differential Resting State Connectivity Patterns and Impaired Semantically Cued List Learning Test Performance in Early Course Remitted Major Depressive Disorder.
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DOI：
10.1017/s1355617716000011
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Langenecker SA
中科院分区：
文献类型：
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作者：
Rao JA;Jenkins LM;Hymen E;Feigon M;Weisenbach SL;Zubieta JK;Langenecker SA
众所周知，记忆障碍和重度抑郁症（MDD）之间存在关联。此外，最近的研究也显示静息状态（rs）功能磁共振成像异常活动和缓解MDD。然而，迄今为止还没有研究既检查静息状态连接和记忆性能在早期缓解的MDD，也没有连接和语义线索情节记忆之间的关系。使用海马中的双侧种子，从34名未用药的18-23岁的MDD缓解（rMDD）年轻人和23名健康对照（HC）中收集来自两台3.0特斯拉GE扫描仪的静息状态MRI（rsMRI）数据。参与者还完成了语义线索列表学习测试，他们的表现与基于海马种子的rsMRI相关。回归模型也被用来预测连接模式的记忆性能。在校正性别后，rMDD在回忆和识别的单词总数上表现得比HC差。与HC相比，rMDD表现出海马和多个额颞区之间的显著网络内低激活，以及海马和额顶叶区之间的多个网络外超连接。内存性能的负预测的连接HC和积极预测的连接rMDD。即使有MDD病史的个体不再表现出活动性抑郁症状，他们仍然表现出更差的记忆表现，海马连接中断，以及情节记忆和海马连接之间的差异关系。
There is a well-known association between memory impairment and Major Depressive Disorder (MDD). Additionally, recent studies are also showing resting-state (rs) fMRI abnormalities in active and remitted MDD. However, no studies to date have examined both resting state connectivity and memory performance in early course remitted MDD, nor the relationship between connectivity and semantically-cued episodic memory. Resting state MRI (rsMRI) data from two 3.0 Tesla GE scanners were collected from 34 unmedicated young adults with remitted MDD (rMDD) and 23 healthy controls (HCs) between 18–23 years of age using bilateral seeds in the hippocampus. Participants also completed a semantically-cued list-learning test and their performance was correlated with hippocampal seed-based rsMRI. Regression models were also used to predict connectivity patterns from memory performance. After correcting for sex, rMDD performed worse than HCs on the total number of words recalled and recognized. rMDD demonstrated significant in-network hypoactivation between the hippocampus and multiple fronto-temporal regions, and multiple extra-network hyperconnectivities between the hippocampus and fronto-parietal regions when compared to HCs. Memory performance negatively predicted connectivity in HCs and positively predicted connectivity in rMDD. Even when individuals with a history of MDD are no longer displaying active depressive symptoms, they continue to demonstrate worse memory performance, disruptions in hippocampal connectivity, and a differential relationship between episodic memory and hippocampal connectivity.