Ambient Air Pollution Correlates with Hospitalizations for Inflammatory Bowel Disease: An Ecologic Analysis
Ambient Air Pollution Correlates with Hospitalizations for Inflammatory Bowel Disease: An Ecologic Analysis
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DOI：
10.1002/ibd.21455
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发表时间：
2011-05-01
影响因子：
4.9
通讯作者：
Saeian, Kia
中科院分区：
文献类型：
--
作者：
Ananthakrishnan, Ashwin N.;McGinley, Emily L.;Saeian, Kia
背景资料：已知的遗传位点占炎症性肠病（IBD）风险的不到25%，这表明环境触发因素的潜在作用。环境空气污染和IBD住院治疗之间的关联以前没有studyed.Methods：数据从威斯康星州医院协会（WHA）为2002年被用来确定IBD相关的住院治疗的数量为每个威斯康星州的72个县。从环境保护局获得每个县的六种标准污染物的平均年排放密度（2002年）。结果：各县IBD住院率为81.3/10万（0 - 174），各县IBD住院率为100，000/10万（0-174）。总标准污染物排放密度与成人IBD住院率显著相关（Pearson相关系数（rho）0.28，P = 0.02）。在泊松回归中，总标准污染物排放密度增加1个对数与IBD住院率增加40%相关（发生率比[IRR] 1.40，95%置信区间[CI] 1.31-1.50）这与溃疡性结肠炎（UC）相似（IRR 1.48，95% CI 1.27-1.73）和克罗恩病（CD）住院（IRR 1.39，95% CI 1.26-1.52）。每个单独的标准污染物排放密度的分析揭示了一个显着的关联，所有的组件标准pollutants.Conclusions：在这个生态分析，总的空气排放标准污染物似乎与成人IBD住院治疗。生态学设计排除了得出关于关联或因果关系的坚定结论，需要进一步的研究。（炎症性肠病2011;17：1138-1145）
Background: Known genetic loci account for less than 25% of the risk for inflammatory bowel disease (IBD), suggesting a potential role for environmental triggers. The association between ambient air pollution and IBD hospitalizations has not been previously studied.Methods: Data from the Wisconsin Hospital Association (WHA) for the year 2002 was used to identify the number of IBD-related hospitalizations for each of the 72 counties in Wisconsin. Average annual emissions density (2002) for each of the six criteria pollutants were obtained for each county from the Environmental Protection Agency. Pearson correlation and Poisson regression analysis were performed at the level of the county.Results: There was a mean of 81.3 IBD hospitalizations/100,000 population per county (range 0-174). The total criteria pollutant emissions density correlated significantly with adult IBD hospitalizations (Pearson's correlation coefficient (rho) 0.28, P = 0.02). On Poisson regression, a 1-log increase in the density of total criteria pollutant emission was associated with a 40% increase in the rate of IBD hospitalizations (incidence rate ratio [IRR] 1.40, 95% confidence interval [CI] 1.31-1.50) This was similar for both ulcerative colitis (UC) (IRR 1.48, 95% CI 1.27-1.73) and Crohn's disease (CD) hospitalizations (IRR 1.39, 95% CI 1.26-1.52). Analysis of each of the individual criteria pollutant emission densities revealed a significant association for all the component criteria pollutants.Conclusions: In this ecologic analysis, total air emissions of criteria pollutants appear to be associated with hospitalizations for IBD in adults. The ecologic design precludes drawing firm conclusions about association or causality and further research is needed. (Inflamm Bowel Dis 2011;17:1138-1145)