Imaging features of combined hepatocellular-cholangiocarcinoma on contrast-enhanced ultrasound: correlation with clinicopathological findings
Imaging features of combined hepatocellular-cholangiocarcinoma on contrast-enhanced ultrasound: correlation with clinicopathological findings
复制标题
DOI：
10.1016/j.crad.2017.10.003
复制
发表时间：
2018-03-01
影响因子：
2.6
通讯作者：
Huang, G.
中科院分区：
文献类型：
--
作者：
Ye, J.;Xie, X.;Huang, G.
目的：评估复合性肝细胞胆管癌（CHC）的超声造影（CEUS）影像学特征与临床病理结果之间的关系。 材料和方法：2004年8月至2016年8月，对40例经组织病理学证实患有CHC的患者（29名男性，11名女性；平均年龄52.8+/-11.2岁）进行了调查。回顾性分析比较CHC的CEUS影像学特征和临床病理结果。结果：CEUS显示周围不规则边缘状强化、弥漫性不均匀强化和弥漫性均匀强化，分别有13个（32.5%）、21个（52.5%）和6个（15%）病灶。组织病理学结果显示，整个肿瘤中肝细胞癌 (HCC) 和胆管癌 (CC) 分别占 21 例 (52.5%) 和 19 例 (47.5%)。 HCC为主的CHC比外周不规则边缘状强化更频繁地表现出弥漫性不均匀强化（p = 0.005），而CC为主的CHC比弥漫性不均匀强化和均匀增强更频繁地表现出外周不规则边缘状强化（分别为p = 0.005和p = 0.01）。 >5 cm 的 CHC 表现出弥漫性不均匀强化的频率高于弥漫性均匀强化，而 CHC 则更频繁地表现出弥漫性不均匀强化。
AIM: To evaluate the relationship between the imaging features of combined hepatocellular-cholangiocarcinoma (CHC) on contrast-enhanced ultrasound (CEUS) and clinicopathological findings.MATERIALS AND METHODS: From August 2004 to August 2016, 40 patients (29 males, 11 females; mean age 52.8 +/- 11.2 years) with histopathologically proven CHC were investigated. The CEUS imaging features and clinicopathological findings of CHC were analysed and compared retrospectively.RESULTS: On CEUS, peripheral irregular rim-like enhancement, diffuse heterogeneous enhancement, and diffuse homogeneous enhancement was illustrated in 13 (32.5%), 21 (52.5%), and six (15%) lesions, respectively. Histopathological findings showed hepatocellular carcinoma (HCC) predominance and cholangiocarcinoma (CC) predominance throughout the tumour were illustrated in 21 (52.5%) and 19 (47.5%) cases, respectively. HCC-predominant CHCs displayed diffuse heterogeneous enhancement more frequently than peripheral irregular rim-like enhancement (p=0.005), whereas CC-predominant CHCs displayed peripheral irregular rim-like enhancement more frequently than diffuse heterogeneous enhancement and homogeneous enhancement (p=0.005 and p=0.01, respectively). CHCs >5 cm displayed diffuse heterogeneous enhancement more frequently than diffuse homogeneous enhancement, whereas CHCs