REPRODUCIBILITY OF RESTING CEREBRAL BLOOD-FLOW MEASUREMENTS WITH H215O POSITRON EMISSION TOMOGRAPHY IN HUMANS
REPRODUCIBILITY OF RESTING CEREBRAL BLOOD-FLOW MEASUREMENTS WITH H215O POSITRON EMISSION TOMOGRAPHY IN HUMANS
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DOI：
10.1038/jcbfm.1993.95
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发表时间：
1993-09-01
影响因子：
6.3
通讯作者：
PAUL, SM
中科院分区：
文献类型：
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作者：
MATTHEW, E;ANDREASON, P;PAUL, SM
使用（H_2O）-O-15正电子发射断层扫描法连续两次测量正常志愿者（n = 25）的静息CBF。第一次（40.3 +/- 6.4）和第二次（39.3 +/- 6.5）测量的绝对全脑血流量（WBBF; ml 100 g-1 min-1，平均值+/- SD）无显著差异（平均%差异2.3 +/- 8.7）。感兴趣区域的分析显示绝对区域CBF（rCBF）和标准化（rCBF/WBBF）rCBF无显著差异。左右差异也不显著。这些数据证明了正常人静息CBF测量的可重复性。
Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using (H2O)-O-15 positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g-1 min-1, mean +/- SD) for the first (40.3 +/- 6.4) and second (39.3 +/- 6.5) measurements was not significantly different (mean % difference 2.3 +/- 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.