Paediatric scrub typhus in Thailand: a study of 73 confirmed cases
Paediatric scrub typhus in Thailand: a study of 73 confirmed cases
复制标题
DOI：
10.1016/j.trstmh.2003.10.011
复制
发表时间：
2004-06-01
影响因子：
2.2
通讯作者：
Silpapojakul, K
中科院分区：
文献类型：
--
作者：
Silpapojakul, K;Varachit, B;Silpapojakul, K
我们研究了73名患有恙虫病的泰国儿童（中位年龄9岁，范围3-14岁，男性：女性比例为1.8：1）。大多数患者（86%）生活在农村地区。他们表现为亚急性发热（中位数，9天）伴呕吐（35%）、肝肿大（59%）、脾肿大（18%）和呼吸急促（26%）。皮疹（7%）、焦痂（7%）和螨叮咬史罕见。血白细胞计数通常正常，但19%的患者白细胞减少。20例（22%）患者有肺炎，6例（8%）患者有神经系统受累。多西环素和氯霉素治疗后退热的中位时间分别为1天和3天，这些反应比接受其他抗生素或未治疗的患者更快（P < 0.001）。有一人死亡。只有55%的患者最初被诊断为恙虫病。(C)2004年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
We studied 73 Thai children with scrub typhus (median age 9 years, range 3-14 years, male:female ratio 1.8:1). Most patients (86%) lived in rural areas. They presented with subacute fever (median, 9 d) with vomiting (35%), hepatomegaly (59%), splenomegaly (18%), and tachypnea (26%). Skin rash (7%), eschar (7%), and history of mite bite were rare. Blood leucocyte counts were usually normal but 19% of patients were thrombocytopenic. Twenty (22%) patients had pneumonia and six (8%) had neurological involvement. Defervescence occurred a median of 1 d and 3 d after initiation of doxycycline and chloramphenicol, respectively, and these responses were more rapid than in those who received other antibiotics or no treatment (P < 0.001). There was one death. Only 55% of the patients were initially diagnosed as having scrub typhus. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.