Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs
Inhaled 1,8-Cineole Reduces Inflammatory Parameters in Airways of Ovalbumin-Challenged Guinea Pigs
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DOI：
10.1111/j.1742-7843.2010.00622.x
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Magalhaes, Pedro J. C.
中科院分区：
文献类型：
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作者：
Bastos, Vasco P. D.;Gomes, Antoniella S.;Magalhaes, Pedro J. C.
桉叶醇，也称为1，8-桉叶油素，是一种单萜，由于其分泌溶解特性，传统上用于治疗呼吸系统疾病。除了肌肉松弛作用外，它还具有体外抗炎作用。在这项研究中，我们的目的是评估1，8-桉叶素急性治疗降低气道炎症参数的疗效。卵清蛋白（OVA）致敏的豚鼠进行抗原激发（OVA），通过吸入给予单剂量的1，8-桉叶油素进行预处理或不进行预处理。与未处理的豚鼠相比，在1，8-桉叶油处理的动物中气道炎症参数减少或不存在。用1，8-桉叶素急性治疗可损害离体气管环中卡巴胆碱气道高反应性的发展。促炎细胞因子TNF α和IL-1 β的水平在1，8-桉叶油素处理的豚鼠的支气管肺泡灌洗液（BALF）中低于未处理的动物。1，8-桉叶油素可抑制OVA诱导的BALF髓过氧化物酶活性的升高。1，8-桉叶油素还防止抗原呈递诱导的粘膜纤毛清除的减少。本研究提供的证据表明，吸入1，8-桉叶素防止高反应性和抑制炎症的气道的卵清蛋白攻击的豚鼠。
Eucalyptol, also known as 1,8-cineole, is a monoterpene traditionally used to treat respiratory disorders due to its secretolytic properties. In addition to its myorelaxant effects, it also has anti-inflammatory actions in vitro. In this study, we aimed to evaluate the efficacy of acute treatment with 1,8-cineole on reducing airway inflammatory parameters. Ovalbumin (OVA)-sensitized guinea pigs were submitted to antigenic challenge (OVA) with or without pre-treatment with a single dose of 1,8-cineole administered by inhalation. Airway inflammatory parameters were reduced or absent in 1,8-cineole-treated animals as compared with untreated guinea pigs. Acute treatment with 1,8-cineole impaired the development of airway hyperresponsiveness to carbachol in isolated tracheal rings. Levels of the pro-inflammatory cytokines TNF alpha and IL-1 beta was lower in bronchoalveolar lavage fluid (BALF) of 1,8-cineol-treated guinea pigs than in untreated animals. 1,8-Cineole impaired the OVA-induced increase of the myeloperoxidase activity in BALF. 1,8-Cineole also prevented the reduction of the mucociliary clearance induced by the antigen presentation. The present investigation provides evidence that inhaled 1,8-cineole prevents hyperresponsiveness and inhibits inflammation in airways of ovalbumin-challenged guinea pigs.