Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins
Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins
复制标题
环糊精中芳香族化合物的区域选择性 C-H 三氟甲基化
DOI：
10.1021/acs.orglett.1c01259
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发表时间：
2021
期刊：
影响因子：
5.2
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Lu;X.; Kawazu;R.; Song;J.; Yoshigoe;Y.; Torigoe;T.; Kuninobu;Y.
以环糊精(CDS)为添加剂，研究了芳香族化合物的区域选择性自由基C-H三氟甲基化反应。C-H三氟甲基化反应具有很高的区域选择性，即使在克级规模上也能以较高的产率得到产品。在硫化镉存在下，一些底物选择性地发生了单一的三氟甲基化反应，而在没有硫化镉存在的情况下，形成了单一和双三氟甲基化产物的混合物。1H核磁共振实验表明，区域选择性是由CD空腔内的底物所控制的。
A regioselective radical C–H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C–H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD.1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity.