Endogenous circannual clock and HP complex in a hibernation control system.
Endogenous circannual clock and HP complex in a hibernation control system.
复制标题
冬眠控制系统中的内源性生物钟和 HP 复合物。
DOI：
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
N. Kondo
中科院分区：
文献类型：
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作者：
N. Kondo
哺乳动物的冬眠是一种神秘的生物现象，在季节性的基础上出现，以在接近0摄氏度的潜在致命的低体温（Tb）中生存，并在冬眠期间保护生物体免受各种疾病和有害事件的影响。这种独特的能力是季节性发展的确切机制仍然是未知的。在我们以前发现的基础上，钙离子的来源兴奋-收缩偶联在金花鼠，啮齿动物冬眠，季节性调制冬眠，肝衍生的冬眠特异性蛋白（HP）复合物被发现。最近，HP复合物被鉴定为一种有前途的候选激素，其独立于Tb和环境变化向大脑携带冬眠信号，以发展耐受低Tb的能力。这一发现将促进理解生物冬眠系统的新方法，包括一个昼夜时钟及其在大脑和外周之间的信号通路。提出了一种新的冬眠定义和一种可能的冬眠控制系统模型。
Hibernation in mammals is a mysterious biological phenomenon that appears on a seasonal basis for surviving a potentially lethal low body temperature (Tb) near 0 degrees C and protecting organisms from various diseases and harmful events during hibernation. The exact mechanism by which such a unique ability is seasonally developed is still unknown. On the basis of our previous finding that the source of calcium ions for excitation-contraction coupling in myocardium of chipmunks, a rodent hibernator, is seasonally modulated for hibernation, the liver-derived hibernation-specific protein (HP) complex was discovered. Recently, the HP complex was identified as a promising candidate hormone that carries a hibernation signal to the brain independently of Tb and environmental changes for developing a capacity for tolerating low Tb. This finding will promote new approaches to understanding biological hibernation systems, including a circannual clock and its signaling pathway between the brain and the periphery. A new definition of hibernation and a possible model of a hibernation control system are proposed.
影响因子：
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作者：
KRILOWICZ, BL;GLOTZBACH, SF;HELLER, HC
通讯作者：
HELLER, HC