Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice
Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice
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DOI：
10.1248/bpb.28.937
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发表时间：
2005-05-01
影响因子：
2
通讯作者：
Kitahara, M
中科院分区：
文献类型：
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作者：
Kuroda, M;Mimaki, Y;Kitahara, M
姜黄醇提物显著抑制2型糖尿病KK-A(Y)小鼠血糖水平的升高。在体外评估中，该提取物以剂量依赖的方式刺激人脂肪细胞分化，并在GAL4-PPAR-γ嵌合体实验中显示出人PPAR-γ配体结合活性。其主要成分为姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素和Ar-姜黄酮，并具有PPAR-γ配体结合活性。这些结果表明，姜黄是一种很有前途的预防和/或改善2型糖尿病的功能食品成分，姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素和Ar-姜黄酮主要通过激活PPAR-γ来发挥作用。
The turmeric (Curcuma longa L. rhizomes) EtOH extract significantly suppressed an increase in blood glucose level in type 2 diabetic KK-A(y) mice. In an in vitro evaluation, the extract stimulated human adipocyte differentiation in a dose-dependent manner and showed human peroxisome proliferator-activated receptor (PPAR)-gamma ligand-binding activity in a GAL4-PPAR-gamma chimera assay. The main constituents of the extract were identified as curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone, which had also PPAR-gamma ligand-binding activity. These results indicate that turmeric is a promising ingredient of functional food for the prevention and/or amelioration of type 2 diabetes and that curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone mainly contribute to the effects via PPAR-gamma activation.