N-GLUCOSIDATION OF AMOBARBITAL IN THE CAT
N-GLUCOSIDATION OF AMOBARBITAL IN THE CAT
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DOI：
10.1139/y85-209
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发表时间：
1985-01-01
影响因子：
2.1
通讯作者：
KALOW, W
中科院分区：
文献类型：
--
作者：
CARROCIAMPI, G;JURIMA, M;KALOW, W
N-葡萄糖苷化是巴比妥酸盐代谢的一种新途径，迄今为止已知仅发生在人类中。通过体外筛选进行的动物模型研究显示，在猫的肝脏制剂中形成了异戊巴比妥-N-葡萄糖苷。异戊巴比妥腹腔注射后，在猫尿中证明了异戊巴比妥-N-葡萄糖苷的存在。
N-Glucosidation is a novel pathway of barbiturate metabolism, so far known to occur only in man. A search for an animal model, conducted through in vitro screening, revealed that amobarbital-N-glucoside was formed in liver preparations from the cat. The presence of amobarbital-N-glucoside was demonstrated in cat urine, following i.p. administration of amobarbital.