Effects of Intracordal Estradiol and Dexamethasone Injection on Wound Healing in Vocal Fold Injuries
Effects of Intracordal Estradiol and Dexamethasone Injection on Wound Healing in Vocal Fold Injuries
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DOI：
10.1016/j.jvoice.2018.01.020
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发表时间：
2019-09-01
期刊：
影响因子：
2.2
通讯作者：
Okcu, Oguzhan
中科院分区：
文献类型：
--
作者：
Yildiz, Muhammet;Yigit, Ozgur;Okcu, Oguzhan
目标。本研究旨在探讨雌二醇地塞米松注射对声带损伤创面愈合的影响。研究设计。进行了前瞻性对照动物研究。本研究在某三级中心进行。对象-方法。10只家兔随机分为两组。作为外科手术，在双侧声带的中间三分之一处进行声带切开术。第一组右侧注射地塞米松0.1 mL，左侧注射生理盐水0.1 mL。第二组右侧注射雌二醇0.1 mL，左侧注射生理盐水0.1 mL。1个月后处死动物，对喉部标本进行组织病理学检查。地塞米松和雌二醇注射组与生理盐水注射组在炎症反应、上皮厚度、I型和III型胶原蛋白、透明质酸参数方面均无统计学差异。在弹性蛋白水平方面，雌二醇注射比生理盐水注射具有更高的统计学意义。地塞米松注射后声带弹性蛋白水平与生理盐水注射后比较无统计学差异。雌二醇注射组与地塞米松注射组在声带炎症反应、上皮厚度、I型和III型胶原蛋白及透明质酸参数方面均无显著差异。据认为，雌二醇或地塞米松注射对声带损伤的伤口愈合可能有类似的效果。睾丸内注射雌二醇对组织弹性蛋白水平有积极影响。
Objective. The aim of this study was to investigate the effects of intracordal estradiol and dexamethasone injection on wound healing in vocal fold injuries.Study Design. A prospective controlled animal study was carried out.Setting. This study was conducted at a tertiary center.Subjects-Methods. Ten rabbits were randomly divided into two groups. As surgical procedure, cordotomy technique was performed in the middle third of the vocal folds bilaterally. In the first group, 0.1 mL of dexamethasone was injected into the right side, and 0.1 mL of saline was injected into the left side. In the second group, 0.1 mL of estradiol was injected into the right side, and 0.1 mL of saline was injected into the left side. Animals were sacrificed after 1 month and laryngeal specimens were evaluated histopathologically.Results. No statistically significant difference was observed in terms of inflammatory response, epithelial thickness, type I and III collagen, and hyaluronic acid parameters in dexamethasone and estradiol injections compared to the saline injection. In terms of elastin level, estradiol injection demonstrated statistically higher values compared to the saline injection. Elastin level of dexamethasone injected vocal folds was not statistically different compared to the saline injection. No significant differences were observed in terms of inflammatory response, epithelial thickness, type I and III collagen, and hyaluronic acid parameters between the estradiol and dexamethasone injected vocal folds.Conclusion. It is thought that the effects of estradiol or dexamethasone injections may have similar effects on wound healing in vocal fold injuries. Intracordal estradiol injection has positive effects on tissue elastin levels.