Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol
Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol
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DOI：
10.1021/acs.orglett.5b02851
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发表时间：
2015-11-06
期刊：
影响因子：
5.2
通讯作者：
Aube, Jeffrey
中科院分区：
文献类型：
--
作者：
Motiwala, Hashim F.;Vekariya, Rakesh H.;Aube, Jeffrey
芳基烷基氯在1,1,1,3,3,3-六氟-2-丙醇中的简单溶解促进了分子内的Friedel Crafts酰化，而不需要额外的催化剂或试剂。该反应在执行和产物分离操作上都很简单（只需要浓缩然后纯化），并且适用于广泛的底物。对潜在的反应机制进行了初步研究。
Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.