Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life
Depression Prevalence in Neuropathic Pain and Its Impact on the Quality of Life
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DOI：
10.1155/2020/7408508
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发表时间：
2020-06-16
影响因子：
2.9
通讯作者：
Damak, Rahma
中科院分区：
文献类型：
--
作者：
Cherif, Farah;Zouari, Hela G.;Damak, Rahma
导言。神经性疼痛的治疗仍然很复杂，通常是因为精神疾病的共病经常被低估。我们的工作目标是确定抑郁症与NP的特征和生活质量之间的联系，在咨询神经病理性疼痛(NP)而不考虑病因的受试者样本中。我们对61名神经病理性疼痛咨询患者进行了横断面研究，评估了5个参数，即基于DN4的神经病理性疼痛、使用EVA的疼痛强度、根据HADS和生活质量的焦虑和抑郁。研究人群平均年龄为52.71±14.29岁，性别比为0.52。神经性疼痛最常见的原因是带状疱疹后疼痛、腕管综合征和糖尿病神经病变。抑郁和焦虑的比例分别为65.6%和73.7%。生活质量受损，SF-12躯体和精神平均得分分别为33.76±8.03和37.78+/-11.52。总体平均BPI评分为5.53+/-1.76。DN4评分越高的患者抑郁程度越高(p=0.025)。抑郁评分与疼痛强度呈显著正相关(p=0.001，r=0.41)。根据SF-12和BPI，抑郁症患者的生活质量较差。考虑到抑郁共病对神经病理性疼痛成分和生活质量的影响，筛查这种共病应该是基线ND评估的一部分。
Introduction. The management of neuropathic pain remains complex, generally because of the psychiatric comorbidity that is often underdiagnosed. The objectives of our work were to determine the link between depression and the characteristics of NP on the one hand and quality of life on the other hand, in a sample of subjects consulting for neuropathic pain (NP) regardless of etiology.Methods. We conducted a cross-sectional study involving 61 neuropathic pain consulting patients in whom we assessed five parameters, namely, neuropathic pain based on DN4, pain intensity using EVA, anxiety, and depression according to the HADS and quality of life.Results. The study population mean age was 52.71 +/- 14.29 years while the sex ratio (m/f) was 0.52. The neuropathic pain's most common etiologies were postherpetic pain, carpal tunnel syndrome, and diabetic neuropathy. Depression and anxiety prevailed by 65.6% and 73.7%, respectively. The quality of life was impaired with average SF-12 physical and mental scores of 33.76 +/- 8.03 and 37.78 +/- 11.52, respectively. The overall mean BPI score was 5.53 +/- 1.76. Patients with high DN4 scores were significantly more depressed (p=0.025). A significantly positive association was found between the depression score and the pain intensity (p=0.001,r = 0.41). Depressed subjects had a poor quality of life according to SF-12 and BPI.Conclusion. Given the depressive comorbidity impact on the neuropathic pain components as well as the quality of life, screening for this comorbidity should be part of the baseline ND assessment.