Meta-analysis of the effects of behavioral HIV prevention interventions on the sexual risk behavior of sexually experienced adolescents in controlled studies in the United States
Meta-analysis of the effects of behavioral HIV prevention interventions on the sexual risk behavior of sexually experienced adolescents in controlled studies in the United States
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DOI：
10.1097/01.qai.0000019980.12814.df
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发表时间：
2002-07-01
期刊：
影响因子：
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通讯作者：
Sogolow, E
中科院分区：
文献类型：
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作者：
Mullen, PD;Ramírez, G;Sogolow, E
为了评估行为和社会干预对美国性经验丰富的青少年中HIV性风险的影响，并评估与结果差异相关的因素，我们从HIV/ALDS预防研究综合项目数据库中选择了研究。1988年至1998年期间发表或报告的20项研究符合标准：16项提供了足够的数据：其中15项评估行为干预，1项社会干预。汇总优势比(OR)和95%可信区间(CI)，按研究精度加权，表明不使用避孕套的性行为显著减少(研究数量，k，13：or。0.66；CI，0.55-0.79)和较低的行为风险(k，2；OR。0.66：CI，0.50-0.88)，但伴侣数(k，8；OR，0.89：CI，0.76-1.05)和性病(k，2；OR.1.18：CI，0.48-2.86)。综合的性行为风险变量(k，每项研究的M1结局、偏好顺序、不使用避孕套的性行为、性伴数量、风险指数)用于异质性和发表偏倚检验和分层分析。总体而言，这些干预措施对有性经验的青少年有显著的保护作用(k.w，OR，0.65；CI，0.50-0.85)，尽管有发表偏见的暗示。研究设计和干预变量不能解释结果差异。一个探索性的发现可能值得调查：对班外(k，5)民族进行的干预测试比对混合民族(k，11)进行的班内干预效果更大，无论混合群体是-(k，6)还是班外(k，5)。
To estimate the effect of behavioral and social interventions oil sexual risk of HIV among sexually experienced adolescents in the United States and to assess factors associated with variation in outcomes, we selected studies from the HIV/AlDS Prevention Research Synthesis project database. Twenty studies published or reported during the years 1988 through 1998 met criteria: 16 presented sufficient data: of these, 15 evaluated behavioral interventions and I a social intervention. Summary odds ratios (ORs) and 95% confidence intervals (CIs), weighted by study precision, indicated significantly less sex without condoms (number of Studies, k, 13: OR. 0.66; CI, 0.55-0.79) and lower behavioral risk (k, 2; OR. 0.66: CI, 0.50-0.88), but no difference in number of partners (k, 8; OR, 0.89: CI, 0.76-1.05) or STDs (k, 2; OR. 1.18: CI, 0.48-2.86). A composite sexual risk behavior variable (k, M 1 outcome per study, preferred order, sex without condoms, number of partners, risk index) was used for heterogeneity and publication bias tests and stratified analyses. Overall, these interventions had a significant protective effect on sexually experienced adolescents (k. W OR, 0.65; CI, 0.50-0.85), although there was a suggestion of Publication bias. Study design and intervention variables did not explain outcome variation. An exploratory finding may merit investigation: interventions tested with sin-le ethnic groups out-of-class (k, 5) had larger effects than in-class interventions with mixed ethnic groups (k, 11), whether the mixed groups were in- (k, 6) or out-of class (k, 5).