Spatial representation in the entorhinal cortex
Spatial representation in the entorhinal cortex
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DOI：
10.1126/science.1099901
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发表时间：
2004-08-27
期刊：
影响因子：
56.9
通讯作者：
Moser, MB
中科院分区：
文献类型：
--
作者：
Fyhn, M;Molden, S;Moser, MB
内嗅皮层作为海马和新皮层之间的界面，在记忆中可能起着关键作用。为了确定信息是如何在这一领域表示，我们测量了空间调制的神经活动层内侧内嗅皮质投射到海马。靠近后鼻内嗅边界，内嗅神经元有稳定和离散的多峰位置场，预测大鼠的位置准确的位置细胞在海马。精确的位置调制没有观察到更多的ventromedially在内嗅皮层或上游的后嗅皮层，这表明感觉输入被转化为持久的allocentric空间表示内部的背尾内侧内嗅皮层。
As the interface between hippocampus and neocortex, the entorhinal cortex is likely to play a pivotal role in memory. To determine how information is represented in this area, we measured spatial modulation of neural activity in layers of medial entorhinal cortex projecting to the hippocampus. Close to the postrhinal-entorhinal border, entorhinal neurons had stable and discrete multipeaked place fields, predicting the rat's location as accurately as place cells in the hippocampus. Precise positional modulation was not observed more ventromedially in the entorhinal cortex or upstream in the postrhinal cortex, suggesting that sensory input is transformed into durable allocentric spatial representations internally in the dorsocaudal medial entorhinal cortex.