Identification of a novel polyomavirus in wild Sonoran Desert rodents of the family Heteromyidae
Identification of a novel polyomavirus in wild Sonoran Desert rodents of the family Heteromyidae
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DOI：
10.1007/s00705-023-05877-5
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发表时间：
2023-10-01
影响因子：
2.7
通讯作者：
Varsani，Arvind
中科院分区：
文献类型：
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作者：
Vargas，Karla L.;Kraberger，Simona;Varsani，Arvind
啮齿动物是哺乳动物中最大和最多样化的群体。啮齿类动物涵盖了广泛的结构和功能适应，成功地占据了几乎所有的陆地栖息地，它们经常与人类，家畜和野生动物密切相关。虽然大量的研究集中在啮齿动物作为已知的人畜共患病病毒宿主的突出地位上，但对啮齿动物的病毒生态学的重视程度一般较低。在这里，我们利用病毒宏基因组学的方法来调查多瘤病毒在野生啮齿动物从下加利福尼亚半岛，墨西哥，使用粪便样本。我们在两种啮齿动物的粪便样本中发现了一种新的多瘤病毒，一种是棘齿鼠（Chaetodipus spinatus），另一种是Dulzura袋鼠鼠（Dipodomys simulans）。这两种多瘤病毒是β多瘤病毒属中的一个新种。该多瘤病毒簇的序列与其他啮齿动物多瘤病毒和其他两种已在人呼吸道中鉴定的非啮齿动物多瘤病毒（WU和KI）的序列在遗传学上同源。通过我们对七种啮齿动物的持续研究，我们奋进探索与下加利福尼亚半岛上野生啮齿动物相关的病毒多样性，并扩展啮齿动物病毒生态学和进化的现有知识。
Rodents are the largest and most diverse group of mammals. Covering a wide range of structural and functional adaptations, rodents successfully occupy virtually every terrestrial habitat, and they are often found in close association with humans, domestic animals, and wildlife. Although a significant amount of research has focused on rodents’ prominence as known reservoirs of zoonotic viruses, there has been less emphasis on the viral ecology of rodents in general. Here, we utilized a viral metagenomics approach to investigate polyomaviruses in wild rodents from the Baja California peninsula, Mexico, using fecal samples. We identified a novel polyomavirus in fecal samples from two rodent species, a spiny pocket mouse (Chaetodipus spinatus) and a Dulzura kangaroo rat (Dipodomys simulans). These two polyomaviruses represent a new species in the genusBetapolyomavirus. Sequences of this polyomavirus cluster phylogenetically with those of other rodent polyomaviruses and two other non-rodent polyomaviruses (WU and KI) that have been identified in the human respiratory tract. Through our continued work on seven species of rodents, we endeavor to explore the viral diversity associated with wild rodents on the Baja California peninsula and expand on current knowledge of rodent viral ecology and evolution.