Electrochemical Determination of D-Glucose Using Nortropine-N-oxyl under Physiological Conditions
Electrochemical Determination of D-Glucose Using Nortropine-N-oxyl under Physiological Conditions
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DOI：
10.1002/elan.201500059
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发表时间：
2015-10
期刊：
影响因子：
3
通讯作者：
Katsuhiko Sato;Tetsuya Ono;Kentaro Yoshida;Toshinori Ito;Yoshitomo Kashiwagi
中科院分区：
文献类型：
--
作者：
Katsuhiko Sato;Tetsuya Ono;Kentaro Yoshida;Toshinori Ito;Yoshitomo Kashiwagi
以去甲托品为原料，一步合成了去甲托品-N-氧基（NNO）。在pH7.0的磷酸盐缓冲溶液中，用循环伏安法研究了NNO的电催化活性。乙醇、异丙醇和葡萄糖的阳极氧化峰电流增强，表明NNO的电催化作用使这些醇氧化。克里思衍生物（4-羟基-2，2，6，6-四甲基哌啶N-氧自由基）在相同条件下不能氧化醇类化合物。研究了NNO对葡萄糖的电化学响应。阳极峰电流随葡萄糖浓度的增加而增加。获得了对范围为0.1至10 mM的葡萄糖浓度的线性响应。
Nortropine-N-oxyl (NNO) was synthesized in a single step from nortropine. The electrocatalytical activity of NNO was evaluated by cyclic voltammetry in pH7.0 phosphate buffer solution. The anodic peak current for ethanol, isopropanol and glucose was enhanced, showing these alcohols were oxidized by electrocatalytic effect of NNO. On the other hand, TEMPO derivative (4-hydroxy-2,2,6,6,-terramethylpiperidine N-oxyl free radical) could not oxidize the alcohols under the same condition. The electrochemical response of the NNO to glucose was investigated. The anodic peak current increased with an increase in the concentration of glucose. A linear response to the glucose concentration ranging from 0.1 to 10 mM was obtained.