Frequency Dependent Effects of d‐Sotalol and Amiodarone on the Action Potential Duration of the Human Right Ventricle
Frequency Dependent Effects of d‐Sotalol and Amiodarone on the Action Potential Duration of the Human Right Ventricle
复制标题
d-索他洛尔和胺碘酮对人右心室动作电位持续时间的频率依赖性影响
DOI：
10.1111/j.1540-8159.1992.tb03029.x
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
S. Yli‐Mäyry
中科院分区：
文献类型：
--
作者：
H. Huikuri;S. Yli‐Mäyry
在14例接受电生理检查的患者中研究了d-索他洛尔（2.0 mg/kg IV，n = 6）和胺碘酮（400 mg/天，持续3个月，n = 9）对动作电位时程（APD）的频率依赖性效应。在5种不同稳态起搏周期长度（700 msec、600 msec、500 msec、400 msec和350 msec）和心室额外刺激期间，分别在d-索他洛尔和胺碘酮之前和之后，以300 msec至1000 msec的偶联间期记录右心室单相动作电位。D索他洛尔在缓慢稳态刺激速率下导致APD延长（周期长度为700 msec时为11 ± 5%），在更快周期长度下衰减（周期长度为350 msec时为5 ± 3%）。胺碘酮后APD延长与起搏频率无关，例如，周期长度为700 msec时为12 ± 9%，周期长度为350 msec时为11 ± 6%。在d-索他洛尔给药后周期长度突变期间观察到类似的APD频率依赖性延长，而胺碘酮在不同的小囊外间期引起APD均匀延长。因此，d-索他洛尔（一种非选择性钾通道阻断剂）对人心室APD具有反向使用依赖性作用，而胺碘酮具有更高的钾通道选择性，在快速和慢速心率下延长心室APD的能力相同。
Frequency dependent effects of d‐Sotalol (2.0 mg/kg IV, n = 6) and amiodarone (400 mg/day for 3 months, n = 9) were studied on the action potential duration (APD) in 14 patients who underwent electrophysiological testing. Monophasic action potentials were recorded from the right ventricle at five different steady‐state paced cycle lengths (700 msec, 600 msec, 500 msec, 400 msec, and 350 msec), and during ventricular extra stimuli with coupling intervals between 300 msec and 1000 msec, before and after d‐sotalol and amiodarone, respectively. D‐sotalol caused a prolongation of the APD at slow steady‐state stimulation rates (11 ± 5% at cycle length of 700 msec), which became attenuated at faster cycle lengths (5 ± 3% at cycle length of 350 msec). Prolongation of APD after amiodarone was independent of pacing rate, e.g., 12 ± 9% at cycle length of 700 msec, and 11 ± 6% at cycle length of 350 msec. Similar frequency dependent prolongation of the APD was observed during abrupt changes of cycle lengths after d‐sotalol, whereas amiodarone caused uniform prolongation of the APD at different extrasfimulus intervals. Thus, d‐sotalol, a nonselective potassium channel blacker, has reverse use‐dependent effects on the human ventricular APD, while amiodarone with greater potassium channel selectivity, has equal ability to prolong the ventricular APD at fast and slow heart rates.
长期施用胺碘酮对体内犬心室心肌的速率相关电生理效应。
影响因子：
37.8
作者：
Anderson,KP;Walker,R;Dustman,T;Lux,RL;Ershler,PR;Kates,RE;Urie,PM
通讯作者：
Urie,PM