IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF IMMUNOGLOBULIN-G IN HUMAN-PLACENTA
IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF IMMUNOGLOBULIN-G IN HUMAN-PLACENTA
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DOI：
10.1177/28.4.6768794
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发表时间：
1980-01-01
影响因子：
3.2
通讯作者：
LIN, CT
中科院分区：
文献类型：
--
作者：
LIN, CT
人成熟胎盘Ig[免疫球蛋白]G分子的免疫电镜显示，IgG结合于微绒毛表面和合胞滋养细胞内吞囊泡内壁。含有结合和未结合的IgG分子的内吞囊泡倾向于相互融合或与其他细胞器融合，特别是与溶酶体融合。吞噬溶酶体在细胞基底区更为丰富。显然，一些IgG分子不能被溶酶体酶消化。含有残余IgG的囊泡与基底和基底外细胞膜融合，并通过胞吐作用将其内容物排入细胞外间隙。IgG分子明显通过滋养细胞基底膜和间质间隙向内皮细胞基底膜扩散。IgG分子随后通过内皮间隙和内皮间隙迁移到胎儿血管腔内。
Immunoelectron microscopy of Ig[immunoglobulin]G molecules in human mature placenta showed that IgG bound to microvillar surfaces and the inner wall of endocytotic vesicles of syncytiotrophoblasts. The endocytotic vesicles, containing bound and unbound IgG molecules, tended to fuse with each other or with other cellular organelles, particularly with lysosomes. The phagolysosomes were more abundant in the basal regions of the cells. Apparently, some IgG molecules were not digested by lysosomal enzymes. Vesicles with residual IgG fused with the basal and basolateral cell membrane and discharged their contents into the extracellular space by exocytosis. IgG molecules were apparently transported through the trophoblastic basement membrane and the interstitial space by diffusion to the endothelial basement membrane. The IgG molecules then migrated into the fetal vascular lumen via endothelial gaps and interendothelial spaces.