The Current Duration Approach to Estimating Time to Pregnancy
The Current Duration Approach to Estimating Time to Pregnancy
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DOI：
10.1111/j.1467-9469.2012.00798.x
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发表时间：
2012-06-01
影响因子：
1
通讯作者：
Slama, Remy
中科院分区：
文献类型：
--
作者：
Keiding, Niels;Hansen, Oluf K. Hojbjerg;Slama, Remy
。怀孕时间 (TTP) 是指从一对夫妇开始尝试怀孕到成功的持续时间。它被认为是测量人类自然繁殖力的最直接方法之一。用于设计和分析妊娠时间研究的统计工具属于生存分析，但有几个特征需要特别注意。前瞻性设计很难实施，而在这一领域广泛使用的回顾性（基于怀孕的）设计无法有效地将无子女的夫妇纳入其中。第三种可能的设计从当前试图怀孕的夫妇的横截面样本开始，使用当前持续时间（向后复发时间）作为估计 TTP 的基础。然后，在加速失效时间模型中最方便地进行回归分析。本文调查了在法国生育力流行病学观察站 (Obseff) 进行的大型电话调查中实施这种方法的一些实际和技术统计问题。
. Time-to-pregnancy (TTP) is the duration from the time a couple starts trying to become pregnant until they succeed. It is considered one of the most direct methods to measure natural fecundity in humans. Statistical tools for designing and analysing time to pregnancy studies belong to survival analysis, but several features require special attention. Prospective designs are difficult to carry out and retrospective (pregnancy-based) designs, being widely used in this area, do not allow efficiently including couples remaining childless. A third possible design starts from a cross-sectional sample of couples currently trying to become pregnant, using current duration (backward recurrence time) as basis for the estimation of TTP. Regression analysis is then most conveniently carried out in the accelerated failure time model. This paper surveys some practical and technical-statistical issues in implementing this approach in a large telephone-based survey, the Epidemiological Observatory of Fecundity in France (Obseff).