Egocentric boundary vector tuning of the retrosplenial cortex
Egocentric boundary vector tuning of the retrosplenial cortex
复制标题
DOI：
10.1101/702712
复制
发表时间：
2019-07
期刊：
影响因子：
13.6
通讯作者：
A. Alexander;Lucas C. Carstensen;J. Hinman;F. Raudies;G. Chapman;M. Hasselmo
中科院分区：
文献类型：
--
作者：
A. Alexander;Lucas C. Carstensen;J. Hinman;F. Raudies;G. Chapman;M. Hasselmo
压后皮质神经元将环境边界的位置编码为相对于动物本身的坐标。压后皮质与空间认知中涉及的多个结构紧密相连，对该区域本身的损伤会产生许多空间障碍。在这里，我们试图在二维环境中的自由探索过程中表征该区域内神经元的空间相关性。我们报告说，很大比例的压后皮质神经元的空间感受野是活跃的，当环境边界定位在一个特定的方向和距离相对于动物本身。我们证明，这个基于矢量的位置信号编码在自我中心的坐标，是本地化的dysgranular后压子区域，是独立的自我运动，是上下文不变的。此外，我们确定了一个亚群的神经元与这种响应特性，与海马θ振荡同步。因此，目前的工作确定了一个强大的自我中心的空间代码在压后皮质，可以促进空间坐标系的转换，并支持锚定，生成和利用allocentric表示。
Retrosplenial cortex neurons encode the positions of environmental boundaries in coordinates relative to the animal itself. The retrosplenial cortex is reciprocally connected with multiple structures implicated in spatial cognition, and damage to the region itself produces numerous spatial impairments. Here, we sought to characterize spatial correlates of neurons within the region during free exploration in two-dimensional environments. We report that a large percentage of retrosplenial cortex neurons have spatial receptive fields that are active when environmental boundaries are positioned at a specific orientation and distance relative to the animal itself. We demonstrate that this vector-based location signal is encoded in egocentric coordinates, is localized to the dysgranular retrosplenial subregion, is independent of self-motion, and is context invariant. Further, we identify a subpopulation of neurons with this response property that are synchronized with the hippocampal theta oscillation. Accordingly, the current work identifies a robust egocentric spatial code in retrosplenial cortex that can facilitate spatial coordinate system transformations and support the anchoring, generation, and utilization of allocentric representations.