Duration of smoking cessation is negatively associated with the magnitude of chronic prostatic inflammation and storage dysfunction in patients with benign prostatic hyperplasia.
Duration of smoking cessation is negatively associated with the magnitude of chronic prostatic inflammation and storage dysfunction in patients with benign prostatic hyperplasia.
复制标题
良性前列腺增生患者的戒烟持续时间与慢性前列腺炎症和储存功能障碍的严重程度呈负相关。
DOI：
10.1111/iju.14320
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Yokoyama O.
中科院分区：
文献类型：
--
作者：
Inamura S;Ito H;Oe H;Seki M;Taga M;Kobayashi M;Yokoyama O.
目的探讨吸烟对良性前列腺增生患者下尿路功能和前列腺炎症的影响及戒烟的益处。方法对2006 ~ 2016年行经尿道前列腺手术的118例良性前列腺增生患者的病历进行分析。他们的吸烟史得到证实。研究吸烟与主要临床参数、国际前列腺症状评分、尿流测量、压力流研究、前列腺炎症程度和血清C反应蛋白水平的关系。此外，戒烟和这些临床参数之间的关系进行了评估。结果非吸烟者的国际前列腺紧张症状评分明显低于吸烟者（1.71vs2.60，P= 0.029）。在压力流量研究中，吸烟持续时间与强烈的排尿欲望（相关系数为- 0.314，P= 0.013）、尿急程度（相关系数为- 0.349，P= 0.008）与初始逼尿肌过度活动时膀胱体积（相关系数为- 0.417，P= 0.021）呈负相关。戒烟时间与慢性前列腺炎程度呈负相关（相关系数- 0.253，P= 0.027）。在压力流量研究中，戒烟持续时间与急迫性（相关系数0.286，P= 0.030）和最大膀胱容量（相关系数0.241，P= 0.050）呈正相关。结论吸烟可能是前列腺增生患者存储功能障碍加重的危险因素。戒烟对改善慢性前列腺炎和存储功能障碍是有效的。
ObjectivesTo evaluate the impact of smoking and the benefit of smoking cessation on lower urinary tract function and prostatic inflammation in patients with benign prostatic hyperplasia.MethodsThe medical records of 118 benign prostatic hyperplasia patients who underwent transurethral prostatic surgery between 2006 and 2016 were analyzed. Their smoking history was confirmed. The relationship between smoking and main clinical parameters, International Prostate Symptom Scores, uroflowmetry, pressure flow study, magnitude of prostatic inflammation and the level of serum C‐reactive protein was investigated. Furthermore, the relationships between smoking cessation and these clinical parameters were assessed.ResultsThe International Prostate Symptom Scores for straining among the non‐smokers were significantly lower than those of the smokers (1.71vs2.60,P= 0.029). In the pressure flow study, there were negative correlations between the duration of smoking and strong desire to void (correlation coefficient −0.314,P= 0.013), urgency (correlation coefficient −0.349,P= 0.008) and bladder volume at initial detrusor overactivity (correlation coefficient −0.417,P= 0.021). The duration of smoking cessation was negatively correlated with the magnitude of chronic prostatic inflammation (correlation coefficient −0.253,P= 0.027). In the pressure flow study, the duration of smoking cessation was positively correlated with urgency (correlation coefficient 0.286,P= 0.030) and maximum cystometric capacity (correlation coefficient 0.241,P= 0.050).ConclusionsSmoking could be a risk factor for the exacerbation of storage dysfunction in benign prostatic hyperplasia patients. Smoking cessation is effective in improving chronic prostatic inflammation and storage dysfunction.