Copper-catalyzed 1,1-difunctionalization of terminal alkynes: a three-component reaction for the construction of vinyl sulfones
Copper-catalyzed 1,1-difunctionalization of terminal alkynes: a three-component reaction for the construction of vinyl sulfones
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DOI：
10.1007/s11426-019-9454-8
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发表时间：
2019-04
期刊：
影响因子：
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通讯作者：
Qi Sun;Linge Li;Liyan Liu;Yu Yang;Zhenggen Zha;Zhiyong Wang
中科院分区：
文献类型：
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作者：
Qi Sun;Linge Li;Liyan Liu;Yu Yang;Zhenggen Zha;Zhiyong Wang
A copper-catalyzed 1,1-difunctionalization of terminal alkynes was achieved via a three-component reaction, providing a variety of vinyl sulfones with good yields and excellent chemo- and stereoselectivity. Preliminary mechanistic studies indicated that the reaction probably underwent a Cu-catalyzed formal C–H insertion to produce an allene intermediate, which was then trapped by a sulfonyl anion to give the corresponding product.
