Pharmacological studies on stimulation-produced analgesia in mice.
Pharmacological studies on stimulation-produced analgesia in mice.
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小鼠刺激镇痛的药理学研究。
DOI：
10.1016/0014-2999(81)90474-x
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发表时间：
1981
影响因子：
5
通讯作者：
W. Buckett
中科院分区：
文献类型：
--
作者：
W. Buckett
通过外周尾部电刺激在小鼠中诱导刺激产生的镇痛（ESPA），随后在52°C热板上监测。在适当的术前用药时间和化合物本身不表现出抗伤害感受作用的剂量下，研究了调节某些神经递质系统的化合物对ESPA的影响。操作儿茶酚胺能、多巴胺能或GABA能系统不会改变ESPA。5-羟基-D，L-色氨酸（80-120 mg/kg）可增强5-羟色胺能活性，在某些情况下，对氯苯丙氨酸（3 × 132 mg/kg）可减少5-羟色胺能活性。然而，5-羟色胺再摄取抑制剂氟西汀（5 mg/kg）和齐美利定（10 mg/kg）没有作用，表明单胺的复杂调节作用。与吗啡耐受小鼠一样，已证明美沙酮和哌替啶耐受小鼠中ESPA的诱导，而慢性纳洛酮治疗并未增强镇痛作用。虽然已经证实了ESPA的纳洛酮可逆性，但第二次急性剂量的纳洛酮（1 mg/kg）并未逆转镇痛作用。ESPA也可以在肾上腺切除的小鼠中被完全诱发。结论ESPA是一种特殊类型的刺激产生的镇痛，持续时间较短，更耐调制比别人，这可能是subserve的功能作用，在响应伤害性刺激。
Stimulation-produced analgesia (ESPA) was induced in mice by peripheral caudal electrostimulation and subsequently monitored on a 52°C hot plate. The effects on ESPA of compounds modulating some neurotransmitter systems were studied at appropriate premedication times and at doses at which the compounds themselves did not exhibit antinociceptive actions. The manipulation of catecholaminergic, dopaminergic or GABAergic systems did not modify ESPA. It could be potentiated by an increase in serotoninergic activity following 5-hydroxy-D,L-tryptophan (80–120 mg/kg) and reduced, under certain circumstances, by serotonin depletion with p-chlorophenylalanine (3 × 132 mg/kg). However the serotonin reuptake inhibitors fluoxetine (5 mg/kg) and zimelidine (10 mg/kg) were without effect indicating a complex modulating role of the monoamine. As with morphine-tolerant mice, the induction of ESPA in mice tolerant to methadone and to meperidine has been demonstrated, while the analgesia was not enhanced by chronic naloxone treatment. Although the naloxone reversibility of ESPA has been confirmed, a second acute dose of naloxone (1 mg/kg) did not reverse the analgesia. ESPA could also be fully elicited in adrenalectomized mice. It is concluded that ESPA is a specific type of stimulation-produced analgesia, shorter in duration and pharmacologically more resistant to modulation than others, which might subserve a functional role in response to noxious stimuli.