THE ROLE OF HUMORAL ANTIBODIES IN THE REJECTION OF RENAL HOMOGRAFTS BY RABBITS
THE ROLE OF HUMORAL ANTIBODIES IN THE REJECTION OF RENAL HOMOGRAFTS BY RABBITS
复制标题
体液抗体在兔同种肾排斥反应中的作用
作者：
J. Klassen;F. Milgrom
27只兔接受同种异体肾移植1只，移植13只，移植2只，移植4只，移植3只。在大多数动物中，排斥反应是通过单核细胞浸润完成的，但在第一次移植的4例，第二次移植的7例，第三次移植的2例中，观察到多形核白细胞聚集或肾皮质坏死。在第一次和第二次移植中，这些“不寻常的”发现叠加在单个核细胞的渗透上，这些移植在几天内被拒绝，但在第三次移植中，似乎没有这种渗透，在1小时内被拒绝。用兔细胞培养的混合凝集试验可检测到移植抗体的形成与组织学结果相关联。因此，大多数但不是所有具有移植抗体的动物都有一种不寻常的移植物排斥反应。相反，所有有这种排斥反应的兔子都有抗体。
Twenty-seven rabbits received 1 renal allograft; 13, 2 grafts; and 4, 3 grafts. In most animals, the rejection was accomplished by mononuclear cell infiltration, but in 4 recipients of the first graft, in 7 recipients of the second graft, and in 2 recipients of the third graft, accumulation of polymorphonuclear leukocytes or renal cortical necrosis was noted. These “unusual” findings were superimposed on mononuclear cell infiltration in the first and second grafts which were rejected within a few days but appeared without such an infiltration in the third grafts, which were rejected within 1 hr. The formation of transplantation antibodies detectable by means of the mixed agglutination test with rabbit cell cultures could be correlated with histological findings. Thus, most but not all animals with transplantation antibodies had an unusual form of graft rejection. Conversely, all rabbits with such rejection did have antibodies.