Gastrointestinal stromal tumor arising in the rectovaginal septum
Gastrointestinal stromal tumor arising in the rectovaginal septum
复制标题
起源于直肠阴道隔膜的胃肠道间质瘤
DOI：
10.1136/ijgc-00009577-200403000-00028
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
I. Miyakawa
中科院分区：
文献类型：
--
作者：
K. Nasu;T. Ueda;S. Kai;H. Anai;Y. Kimura;S. Yokoyama;I. Miyakawa
我们在此报告一罕见的起源于直肠壁的恶性胃肠道间质瘤(GIST)，表现为直肠阴道间隔肿瘤。一名54岁的日本妇女，妊娠4号，第3段，主诉无尿和严重便秘。11年前，她曾因子宫肌瘤接受过子宫切除术和右侧输卵管卵巢切除术。盆腔检查发现直肠阴道间隙有8.5×7.5×7.5 cm的硬肿块。肿瘤下缘距阴道内口2 cm，距肛门2 cm。计算机断层扫描和磁共振成像显示直肠阴道腔内有边界清楚的软组织肿块。膀胱和直肠受压移位明显。结肠镜检查显示肿瘤侵入直肠粘膜。采用腹会阴部直肠切除、后阴道壁切除和盆腔淋巴清扫。切除标本显示直肠黏膜下肿瘤，大小为8×8×7 cm。肿瘤被诊断为恶性胃肠道间质瘤。免疫组织化学分析证实了这一诊断。术后13个月，患者健康状况良好，无复发迹象。妇科医生应该意识到，直肠GIST发生在直肠阴道间隙，是阴道粘膜下肿瘤的鉴别诊断。
We report herein a rare case of malignant gastrointestinal stromal tumor (GIST) originated from the rectal wall, which presented as a tumor on the rectovaginal septum. A 54-year-old Japanese woman, gravida 4, para 3, was admitted complaining of anuresis and severe constipation. She had a history of hysterectomy and right salpingo-oophorectomy for uterine leiomyoma 11 years previously. Pelvic examination revealed an 8.5 × 7.5 × 7.5 cm hard mass in the rectovaginal space. The inferior border of the tumor was 2 cm from the vaginal introitus and 2 cm from the anus. Computed tomography and magnetic resonance imaging showed a well-circumscribed soft-tissue mass filling the rectovaginal space. Urinary bladder and rectum were markedly compressed and displaced. Colon fiberscopy revealed invasion of the tumor into the rectal mucosa. An abdominoperineal resection of the rectum with posterior vaginal wall resection and pelvic lymphadenectomy was performed. The resected specimen showed a rectal submucosal tumor that was 8 × 8 × 7 cm in size. The tumor was diagnosed as a malignant GIST. Immunohistochemical analysis confirmed this diagnosis. The patient is now healthy without evidence of recurrence at 13 months after surgery. Gynecologists should be aware of rectal GIST arising in the rectovaginal space as a differential diagnosis of vaginal submucosal tumor.
Yamaguchi, M.、Miyaki, M.、Iijima, T.、Matsumoto, T.、Kuzume, M.、Matsumiya, A.、Endo, Y.、Sanada, Y.、Kumada, K.：“外显子中的特定突变
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
Hirota, S;Isozaki, K;Kitamura, Y
通讯作者：
Kitamura, Y