STAUFEN, A GENE REQUIRED TO LOCALIZE MATERNAL RNAS IN THE DROSOPHILA EGG
STAUFEN, A GENE REQUIRED TO LOCALIZE MATERNAL RNAS IN THE DROSOPHILA EGG
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DOI：
10.1016/0092-8674(91)90138-o
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发表时间：
1991-07-12
期刊：
影响因子：
64.5
通讯作者：
NUSSLEINVOLHARD, C
中科院分区：
文献类型：
--
作者：
STJOHNSTON, D;BEUCHLE, D;NUSSLEINVOLHARD, C
后组基因Staufen既是将母系决定因素定位到果蝇卵的后极所必需的，也是双核RNA正确定位到前极所必需的。我们报道了Staufen的克隆和测序，并表明Staufen蛋白是最早定位于卵母细胞后极的分子之一，可能与Oskar RNA有关。一旦定位，在极粒中发现了史陶芬，并需要将其他极粒成分保持在后极处。到产卵时，Staufen蛋白也集中在前极，与双核RNA位于同一区域。
The posterior group gene staufen is required both for the localization of maternal determinants to the posterior pole of the Drosophila egg and for bicoid RNA to localize correctly to the anterior pole. We report the cloning and sequencing of staufen and show that staufen protein is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with oskar RNA. Once localized, staufen is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, staufen protein is also concentrated at the anterior pole, in the same region as bicoid RNA.