Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines.
Lipid Nanoparticles as Delivery Systems for RNA-Based Vaccines.
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脂质纳米粒作为RNA疫苗的递送系统。
DOI：
10.3390/pharmaceutics13020206
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发表时间：
2021-02-02
期刊：
影响因子：
5.4
通讯作者：
Almurshedi AS
中科院分区：
文献类型：
--
作者：
Aldosari BN;Alfagih IM;Almurshedi AS
人们对开发基于 RNA 的疫苗以预防各种传染病以及癌症免疫疗法越来越感兴趣。快速且经济高效的制造方法以及在临床前和临床研究中观察到的有效免疫反应使得基于 mRNA 的疫苗有望成为传统疫苗技术的替代品。然而，这些疫苗的有效递送需要保护 mRNA 免受细胞外降解。脂质纳米颗粒 (LNP) 作为将 mRNA 递送至靶细胞的非病毒载体，因其相对简单且可扩展的制造工艺而被广泛研究。本综述重点介绍了 LNP 开发的关键进展，并回顾了 LNP 中配制的基于 mRNA 的疫苗在对抗传染病和癌症方面的应用。
There has been increased interest in the development of RNA-based vaccines for protection against various infectious diseases and also for cancer immunotherapies. Rapid and cost-effective manufacturing methods in addition to potent immune responses observed in preclinical and clinical studies have made mRNA-based vaccines promising alternatives to conventional vaccine technologies. However, efficient delivery of these vaccines requires that the mRNA be protected against extracellular degradation. Lipid nanoparticles (LNPs) have been extensively studied as non-viral vectors for the delivery of mRNA to target cells because of their relatively easy and scalable manufacturing processes. This review highlights key advances in the development of LNPs and reviews the application of mRNA-based vaccines formulated in LNPs for use against infectious diseases and cancer.
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影响因子：
12.4
作者：
Erasmus, Jesse H.;Khandhar, Amit P.;Van Hoeven, Neal
通讯作者：
Van Hoeven, Neal
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
4.9
作者：
Andries, Oliwia;De Filette, Marina;Sanders, Niek N.
通讯作者：
Sanders, Niek N.
影响因子：
5.5
作者：
Aldrich C;Leroux-Roels I;Huang KB;Bica MA;Loeliger E;Schoenborn-Kellenberger O;Walz L;Leroux-Roels G;von Sonnenburg F;Oostvogels L
通讯作者：
Oostvogels L
影响因子：
4.6
作者：
Chahal JS;Fang T;Woodham AW;Khan OF;Ling J;Anderson DG;Ploegh HL
通讯作者：
Ploegh HL