Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice
Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice
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DOI：
10.1016/s0014-2999(99)00003-5
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发表时间：
1999-02-19
影响因子：
5
通讯作者：
Inoue, K
中科院分区：
文献类型：
--
作者：
Hiramatsu, M;Inoue, K
本研究采用小鼠跳台被动回避和Y迷宫自发交替实验，研究了FQ中的Nociceptin/nociceptin和Nocistatin对小鼠学习记忆功能的影响。孤啡肽（0.5-5.0 nmol/小鼠，i. c. v.）训练前30 min或Y-迷宫试验前30 min，剂量依赖性地缩短了跳台潜伏期，并损害了自发交替，而Nocistatin（0.5-5.0 nmol/只）无明显作用。有趣的是，在不改变运动活动或对电击的反应的情况下，伤害抑制素（5.0nmol）显著改善了伤害感受素（5.0nmol）诱导的学习和记忆障碍。这些结果表明，nocistatin是一种新的生物活性肽，也被发现可以对抗伤害感受素引起的学习记忆障碍，在中枢神经系统的学习记忆过程中起着重要的调节作用。(C)1999 Elsevier Science B. V.保留所有权利。
We investigated the effects of nociceptin/orphanin FQ and nocistatin on learning and memory function as measured in a step-down type passive avoidance task and spontaneous alternation of Y-maze with mice. Nociceptin (0.5-5.0 nmol/mouse, i.c.v.) 30 min before the training session or Y-maze test, dose dependently shortened the step-down latency and impaired spontaneous alternation, while there was no significant effect of nocistatin (0.5-5.0 nmol/mouse). interestingly, nocistatin (5.0 nmol) significantly improved the nociceptin (5.0 nmol)-induced impairment of learning and memory without changing motor activity or response to electric shocks. These results suggest that nocistatin, a new biologically active peptide now found to also counteract the impairment of learning and memory induced by nociceptin, plays an important role in the regulation of learning and memory process in the central nervous system. (C) 1999 Elsevier Science B.V. All rights reserved.