Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo.
Effects of tubulin assembly inhibitors on cell division in prokaryotes in vivo.
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DOI：
10.1111/j.1574-6968.2000.tb09314.x
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发表时间：
2000-10
影响因子：
2.1
通讯作者：
M. Sarcina;C. Mullineaux
中科院分区：
文献类型：
--
作者：
M. Sarcina;C. Mullineaux
细菌细胞分裂蛋白FtsZ是微管蛋白的结构类似物。ftsZ基因失活的细菌突变体不能分裂。已知有许多微管蛋白组装抑制剂，其中一些用作杀菌剂。FtsZ和微管蛋白之间强烈的结构同源性提出了其中一些抑制剂可能影响细菌细胞分裂的可能性。在这里，我们报道了微管蛋白组装抑制剂噻苯达唑和2-甲基苯并咪唑引起大肠杆菌和蓝藻的细胞伸长。
The bacterial cell division protein FtsZ is a structural analogue of tubulin. Bacterial mutants in which the ftsZ gene is inactivated are unable to divide. Numerous inhibitors of tubulin assembly are known, some of which are used as fungicides. The strong structural homology between FtsZ and tubulin raises the possibility that some of these inhibitors could affect bacterial cell division. Here we report that the tubulin assembly inhibitors thiabendazole and 2-methylbenzimidazole cause cell elongation in Escherichia coli and cyanobacteria.