Avian leukosis virus subgroup J: a rapidly evolving group of oncogenic retroviruses
Avian leukosis virus subgroup J: a rapidly evolving group of oncogenic retroviruses
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DOI：
10.1053/rvsc.1998.0283
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发表时间：
1999-10-01
影响因子：
2.4
通讯作者：
Venugopal, K
中科院分区：
文献类型：
--
作者：
Venugopal, K
1988年在英国从肉鸡中分离到一株禽白血病病毒(ALV)，属于新的包膜亚群J。自那以后，由该亚群成员引起的疾病在世界范围内迅速传播，并成为肉鸡业面临的主要问题之一。J亚群的原型HPRS-103的分子特征表明，它具有典型的ALV结构，具有gag、pol和env基因。然而，env基因不同于其他ALV的基因，并且与新的内源性逆转录病毒元件Eav-HP的env基因密切相关。由于基因组的其他区域与ALV密切相关，ALV-J被认为是通过与EaV-HP的env序列重组而进化的。ALV-J对髓系细胞有趋向性，这一特征可能与其诱导髓系白血病的能力有关。最近的数据表明，ALV-J分离株进化迅速，导致env基因可变区内的序列发生变化，从而导致抗原变异。事实证明，为其他亚组制定的根除方案在从受感染的禽群中根除ALV-J病毒方面是有效的。(C)1999 HarCourt出版有限公司。
A strain of avian leukosis virus (ALV) belonging to a new envelope subgroup J was isolated in the UK in 1988 from meat-type chickens. The disease caused by the members of this subgroup has since spread very rapidly worldwide and has become one of the major problems facing the broiler meat industry. Molecular characterisation of HPRS-103, the prototype of subgroup J, has shown that it has a structure of a typical ALV With gag, pol and env genes. However the env gene was distinct from that of other ALVs and was closely related to that of novel endogenous retroviral elements designated EAV-HP. AS other regions of the genome were closely related to ALVs, it is believed that ALV-J has evolved by recombination with the env sequences of EAV-HP. ALV-J has a tropism for myeloid cells, a feature that may be associated with its ability to induce myeloid leukosis. Recent data show that ALV-J isolates evolve rapidly resulting in sequence changes within the variable regions of the env gene leading to antigenic variation. Eradication programmes established for other subgroups are proving to be effective in eradicating ALV-J from infected flocks. (C) 1999 Harcourt Publishers Limited.