Pathophysiology of acute wound healing
Pathophysiology of acute wound healing
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DOI：
10.1016/j.clindermatol.2006.09.007
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发表时间：
2007-01-01
影响因子：
2.7
通讯作者：
Kirsner, Robert
中科院分区：
文献类型：
--
作者：
Li, Jie;Chen, Juan;Kirsner, Robert
伤口愈合是一个复杂的过程，可至少分为3个连续且相互重叠的过程：炎症反应、导致组织修复的增殖过程，以及最终的组织重塑。伤口愈合过程受到伤口部位释放的多种生长因子和细胞因子的严格调控。尽管协调愈合的理想最终结果是形成结构和功能与完整皮肤相似的组织，但再生并不常见（早期胎儿愈合等显著例外情况除外）；然而，愈合会产生结构和功能令人满意但不完全相同的结果。破坏受控愈合过程的改变会扩大组织损伤和修复。病理生物学状态可能导致慢性或不愈合的伤口或过度纤维化。（C）2007爱思唯尔公司。保留所有权利。
Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis. (C) 2007 Elsevier Inc. All rights reserved.