On and Off: Epigenetic Regulation of C. albicans Morphological Switches.
On and Off: Epigenetic Regulation of C. albicans Morphological Switches.
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DOI：
10.3390/pathogens10111463
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发表时间：
2021-11-11
期刊：
影响因子：
--
通讯作者：
Buscaino A
中科院分区：
文献类型：
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作者：
Iracane E;Vega-Estévez S;Buscaino A
人类真菌病原体白色念珠菌（Candida albicans）是一种二型机会致病菌，在大多数人群中定植而不造成任何伤害。然而，这种真菌也可能导致免疫功能低下个体的危及生命的感染。成功地定殖不同宿主生态位的能力对于建立感染和发病机制至关重要。C.白色念珠菌可以以各种形态形式生存和分裂，这对其在宿主中的生存至关重要。的确，C。白色念珠菌既可以作为酵母菌也可以作为菌丝生长，并且可以形成含有菌丝的生物膜。控制这些不同形式之间转换的转录调控网络是复杂的，但很容易理解。与此相反，非DNA为基础的表观遗传调制正在成为一个重要的，但仍然缺乏研究的形态转变的监管机制。本文综述了染色质介导的酵母菌菌丝转换和生物膜形成的表观遗传调控。我们强调如何修改染色质结构和非编码RNA有助于这些形态转变。
The human fungal pathogen Candida albicans is a dimorphic opportunistic pathogen that colonises most of the human population without creating any harm. However, this fungus can also cause life-threatening infections in immunocompromised individuals. The ability to successfully colonise different host niches is critical for establishing infections and pathogenesis. C. albicans can live and divide in various morphological forms critical for its survival in the host. Indeed, C. albicans can grow as both yeast and hyphae and can form biofilms containing hyphae. The transcriptional regulatory network governing the switching between these different forms is complex but well understood. In contrast, non-DNA based epigenetic modulation is emerging as a crucial but still poorly studied regulatory mechanism of morphological transition. This review explores our current understanding of chromatin-mediated epigenetic regulation of the yeast to hyphae switch and biofilm formation. We highlight how modification of chromatin structure and non-coding RNAs contribute to these morphological transitions.