Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer
Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer
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DOI：
10.1002/jso.25078
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发表时间：
2018-06-15
影响因子：
2.5
通讯作者：
Park, Kyu J.
中科院分区：
文献类型：
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作者：
Choe, Eun K.;Yi, Jin W.;Park, Kyu J.
肥胖与结直肠癌（CRC）密切相关，但其潜在机制尚不清楚。因此，我们评估了脂肪因子基因家族在结直肠癌组织中的表达及其临床病理意义。方法利用the Cancer Genome Atlas数据库的数据，分析CRC组织中脂肪因子基因家族（ADIPOQ、ADIPOR1/2、LEP、LEPR、RETN、RETNLB、RBP4、SFRP5、NAMPT、SPP1） mRNA表达水平与临床病理因素的关系。结果分析了369例患者的组织样本，随访期间（中位为670天）发生82例死亡。总体而言，死亡率与静脉侵袭阳性、TNM分期升高、ADIPOR1（脂联素受体1基因）和SPP1（分泌磷酸化蛋白基因1）mRNA表达升高有关。较高的ADIPOR1（比值比[OR]: 3.29, 95%可信区间[CI]: 1.33-8.13）和SPP1（比值比：2.31,95%CI: 1.49-3.59）水平与死亡率增加独立相关。Kaplan-Meier生存分析显示，ADIPOR1 （P=0.006）和SPP1 （P=0.006）较高的患者总生存时间较短
BackgroundObesity is closely associated with colorectal cancer (CRC), but the underlying mechanism is unclear. We thus evaluated the expression of the adipokine gene family in CRC tissues and its clinicopathological implications.MethodsCorrelations between the mRNA expression levels of the adipokine gene family (ADIPOQ, ADIPOR1/2, LEP, LEPR, RETN, RETNLB, RBP4, SFRP5, NAMPT, and SPP1) in CRC tissue and clinicopathologic factors were analyzed using data from The Cancer Genome Atlas database.ResultsTissue samples from 369 patients were analyzed, and 82 deaths occurred during follow-up (median, 670 days). Overall, mortality was associated with positive venous invasion, higher TNM stage, and increased ADIPOR1 (adiponectin receptor 1 gene) and SPP1 (secreted phosphoprotein gene 1) mRNA expression. Higher ADIPOR1 (odds ratio [OR]: 3.29, 95% confidence interval [CI]: 1.33-8.13) and SPP1 (OR: 2.31, 95%CI: 1.49-3.59) levels were independently associated with increased mortality. A Kaplan-Meier survival analysis showed shorter overall survival times in patients with higher ADIPOR1 (P=0.006) and SPP1 (P