Role of the amygdala in disrupted integration and effective connectivity of cortico-subcortical networks in apathy
Role of the amygdala in disrupted integration and effective connectivity of cortico-subcortical networks in apathy
复制标题
杏仁核在冷漠中皮质-皮质下网络整合和有效连接中断中的作用
DOI：
10.1093/cercor/bhac267
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Yuejia Luo
中科院分区：
文献类型：
--
作者：
Ningning Zeng;André Aleman;Chong Liao;Huihua Fang;Pengfei Xu;Yuejia Luo
冷漠是一种动机和目标导向行为的定量减少，不仅在神经精神疾病中观察到，而且在健康人群中也存在。虽然大脑异常与冷漠的临床疾病已被研究，在健康individuals.MethodWe脑网络的组织尚未被确定的内在的大脑网络的健康个体的性质与不同程度的冷漠。通过使用功能磁共振成像结合图论分析和动态因果建模分析，我们测试节点和模块之间的通信，以及大脑networks.ResultsWe之间的有效连接发现，皮质下网络的平均参与系数，特别是杏仁核，是较低的个人高比低冷漠。重要的是，我们观察到较弱的有效连接从海马和海马旁回的杏仁核，从杏仁核的海马旁回和内侧额叶皮层的个人与apathy.ConclusionThese研究结果表明，个人具有高度冷漠表现出异常的沟通内的皮层到皮层下网络，其特征在于杏仁核相关的有效连接的差异。我们的工作揭示了亚临床人群冷漠的神经基础，并可能对理解冷漠特征的临床状况的发展产生影响。
BackgroundApathy is a quantitative reduction in motivation and goal-directed behaviors, not only observed in neuropsychiatric disorders, but also present in healthy populations. Although brain abnormalities associated with apathy in clinical disorders have been studied, the organization of brain networks in healthy individuals has yet to be identified.MethodWe examined properties of intrinsic brain networks in healthy individuals with varied levels of apathy. By using functional magnetic resonance imaging in combination with graph theory analysis and dynamic causal modeling analysis, we tested communications among nodes and modules as well as effective connectivity among brain networks.ResultsWe found that the average participation coefficient of the subcortical network, especially the amygdala, was lower in individuals with high than low apathy. Importantly, we observed weaker effective connectivity fromthe hippocampus and parahippocampal gyrus to the amygdala, and from the amygdala to the parahippocampal gyrus and medial frontal cortex in individuals with apathy.ConclusionThese findings suggest that individuals with high apathy exhibit aberrant communication within the cortical-to-subcortical network, characterized by differences in amygdala-related effective connectivity. Our work sheds light on the neural basis of apathy in subclinical populations and may have implications for understanding the development of clinical conditions that feature apathy.