Chromatin challenges during DNA replication: A systems representation
Chromatin challenges during DNA replication: A systems representation
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DOI：
10.1091/mbc.e07-06-0528
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发表时间：
2008-01-01
影响因子：
3.3
通讯作者：
Pommier, Yves
中科院分区：
文献类型：
--
作者：
Kohn, Kurt W.;Aladjem, Mirit I.;Pommier, Yves
在最近的一篇综述中，A. Groth及其同事对核小体在DNA复制叉前的解体、复制叉后的组装以及表观遗传信息复制到复制的染色质上进行了全面的描述。然而，通过类似于电路图的全面图形描述，可以增强对这些过程的理解。因此，我们构建了一个分子相互作用图（MIM），保留了Groth等人描述的过程的基本完整的细节。MIM组织和阐明了Groth等人提出的关于染色质复制复杂性的信息，从而为系统水平理解基因突变、基因表达改变和药物干预的影响提供了工具。
In a recent review, A. Groth and coworkers presented a comprehensive account of nucleosome disassembly in front of a DNA replication fork, assembly behind the replication fork, and the copying of epigenetic information onto the replicated chromatin. Understanding those processes however would be enhanced by a comprehensive graphical depiction analogous to a circuit diagram. Accordingly, we have constructed a molecular interaction map (MIM) that preserves in essentially complete detail the processes described by Groth et al. The MIM organizes and elucidates the information presented by Groth et al. on the complexities of chromatin replication, thereby providing a tool for system-level comprehension of the effects of genetic mutations, altered gene expression, and pharmacologic intervention.