Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation
Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation
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DOI：
10.1016/j.bmcl.2008.12.086
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发表时间：
2009-02-15
影响因子：
2.7
通讯作者：
Landry, Donald W.
中科院分区：
文献类型：
--
作者：
Gong, Gangli;Xie, Yuli;Landry, Donald W.
据报道，IKK β抑制剂可阻断Jurkat T细胞中NF-kappa B的转录活性，并可增强HUVEC细胞中NF-kappa B的易位。这些研究表明，在HUVEC细胞中存在独立于IKK β的非典型NF-kappa B信号通路。(C) 2009年Elsevier Ltd.出版
An IKK beta inhibitor reported to block NF-kappa B transcriptional activities in Jurkat T cells, was found to enhance NF-kappa B translocation in HUVEC cells. These studies suggested a noncanonical NF-kappa B signaling pathway independent of IKK beta in HUVEC cells. (C) 2009 Published by Elsevier Ltd.