The role of protease activity in ErbB biology.
The role of protease activity in ErbB biology.
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DOI：
10.1016/j.yexcr.2008.10.011
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发表时间：
2009-02-15
影响因子：
3.7
通讯作者：
Freeman M
中科院分区：
文献类型：
--
作者：
Blobel CP;Carpenter G;Freeman M
蛋白酶现在被认为除了在蛋白质降解中具有公认的代谢作用外，在各种过程中具有积极作用。在erbbb配体和受体系统中，蛋白酶对于从跨膜前体产生可溶性配体和ErbB4受体的加工是必需的，从而使其胞内结构域易位到细胞核。有两种蛋白酶活动参与了这些事件：在配体（或受体）的外域内切割的蛋白酶和在跨膜区域内切割底物的蛋白酶。前者是ADAM蛋白酶，后者是γ-分泌酶复合物和菱形蛋白酶。这篇综述讨论了这些蛋白酶系统在ErbB系统中的作用。
Proteases are now recognized as having an active role in a variety of processes aside from their recognized metabolic role in protein degradation. Within the ErbB system of ligands and receptors proteases are known to be necessary for the generation of soluble ligands from transmembrane precursers and for the processing of the ErbB4 receptor, such that its intracellular domain is translocated to the nucleus. There are two protease activities involved in the events: proteases that cleave within the ectodomain of ligand (or receptor) and proteases that cleave the substrate within the transmembrane domain. The former are the ADAM proteases and the latter are the γ-secretase complex and the rhomboid proteases. This review discusses the roles of each of these protease systems within the ErbB system.
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影响因子：
7.8
作者：
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通讯作者：
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