HIV-1 Is Associated With Lower Group B Streptococcus Capsular and Surface-Protein IgG Antibody Levels and Reduced Transplacental Antibody Transfer in Pregnant Women
HIV-1 Is Associated With Lower Group B Streptococcus Capsular and Surface-Protein IgG Antibody Levels and Reduced Transplacental Antibody Transfer in Pregnant Women
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DOI：
10.1093/infdis/jiv064
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发表时间：
2015-08-01
影响因子：
6.4
通讯作者：
Madhi, Shabir A.
中科院分区：
文献类型：
--
作者：
Dangor, Ziyaad;Kwatra, Gaurav;Madhi, Shabir A.
背景暴露于人类免疫缺陷病毒（HIV）的婴儿患侵袭性B族链球菌（GBS）疾病的风险增加;然而，这种易感性增加的原因尚未得到表征。我们比较了感染艾滋病毒和未感染艾滋病毒的母亲-新生儿二元组之间的GBS被膜和表面蛋白母体免疫球蛋白G抗体浓度以及脐带-母体比率。结果。HIV感染妇女血清型Ib（P = 0.033）和V（P = 0.040）、菌毛岛（PI）-1（P = 0.016）、PI-2a（P = 0.015）、PI-2b（P = 0.015）和纤维蛋白原结合蛋白A（P <0.001）的中位荚膜抗体浓度（μ g/mL）低于HIV未感染妇女。对于血清型Ia和III，与未感染HIV的母亲-新生儿配对相比，HIV感染者的脐带-母亲比率分别低37.4%（P <0.001）和32.5%（P = 0.027）。当比较HIV感染与未感染的妇女时，对于血清型Ia和III，荚膜抗体浓度= 2 μ g/mL的调整比值分别为0.33（95%置信区间[CI]，0.15 - 0.75）和0.34（95% CI，0.12 -1.00）。抗体水平和脐带-母体比率与CD 4（虚线竖条）淋巴细胞计数或HIV-1病毒载量无关。较低的GBS抗体浓度和减少经胎盘抗体转移的HIV感染的妇女，这可能有助于他们的婴儿在侵袭性GBS疾病的易感性增加，可能会减轻与GBS结合疫苗接种目前正在临床开发。
Background. Human immunodeficiency virus (HIV)-exposed infants are at increased risk of invasive Group B Streptococcus (GBS) disease; however, the reason for this increased susceptibility has not been characterized.Methods. We compared GBS capsular and surface-protein maternal immunoglobin G antibody concentrations and cord-maternal ratios between HIV-infected and HIV-uninfected mother-newborn dyads.Results. Median capsular antibody concentrations (mu g/mL) were lower in HIV-infected than HIV-uninfected women for serotypes Ib (P =.033) and V (P = .040); and for pilus island (PI)-1 (P = .016), PI-2a (P = .015), PI-2b (P = .015), and fibrinogen-binding protein A (P < .001). For serotypes Ia and III, cord-maternal ratios were 37.4% (P < .001) and 32.5% (P = .027) lower in HIV-infected compared to HIV-uninfected mother-newborn dyads. The adjusted odds of having capsular antibody concentration = 2 mu g/mL when comparing HIV-infected to -uninfected women were 0.33 (95% confidence interval [CI], .15-.75) and 0.34 (95% CI, .12-1.00) for serotypes Ia and III, respectively. Antibody levels and cord-maternal ratios were independent of CD4(broken vertical bar) lymphocyte counts or HIV-1 viral load.Conclusions. The lower GBS antibody concentrations and reduced transplacental antibody transfer in HIV-infected women, which likely contribute to their infants being at heightened susceptibility for invasive GBS disease, could possibly be mitigated by vaccination with a GBS conjugate vaccine currently under clinical development.