OBSERVATION OF METABOLITES IN THE HUMAN-BRAIN BY MR SPECTROSCOPY
OBSERVATION OF METABOLITES IN THE HUMAN-BRAIN BY MR SPECTROSCOPY
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DOI：
10.1148/radiology.161.3.3786735
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发表时间：
1986-12-01
期刊：
影响因子：
19.7
通讯作者：
DENHOLLANDER, JA
中科院分区：
文献类型：
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作者：
LUYTEN, PR;DENHOLLANDER, JA
通过氢磁共振（MR）光谱测量低分子量代谢物是复杂的，因为存在来自水和脂质的强烈信号。利用空间分辨光谱（SPARS）技术，结合水信号抑制技术，克服了这一问题。通过SPARS，只能从特定的体积中获得信号，而不能从样品的其余部分获得信号。因此，可以选择大脑中的容量，并且抑制来自其他组织的强烈脂质信号。SPARS技术是基于脉冲磁场梯度的使用，这使得在MR图像的基础上选择敏感体积成为可能。通过施加1331观测脉冲实现了对强水信号的抑制。用这些技巧。用1.5 t全身成像仪成功地测量了人脑中的n -乙酰天冬氨酸，并在猪的脑组织中观察到乳酸。测定低分子量代谢物对评价脑疾病患者具有潜在意义；进一步的研究正在进行中，以评估这种潜力。
Measurement of low molecular weight metabolites by hydrogen magnetic resonace (MR) spectroscopy is complicated by the presence of intense signals from water and lipids. A method of spatially resolved spectroscopy (SPARS), combined with techniques to suppress water signal, was used to overcome this problem. By means of SPARS, a signal can be obtained from a particular volume only, with no signal from the rest of the sample. Thus, a volume in the brain can be selected, and intense lipid signals from other tissue are suppressed. The SPARS technique is based on the use of pulsed magnetic field gradients, which makes it possible to select the sensitive volume on the basis of an MR image. Suppression of the intense water signal was achieved by applying a 1331 observation pulse. With these techniques. N-acetyl aspartate was successfully measured in the human brain with a 1.5-T whole-body imager, and lactate was observed in excised brain tissue of a pig. Measurement of low molecular weight metabolites has potential significance in evaluating patients with diseases of the brain; further studies are underway to assess this potential.