TGF-β-induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM
TGF-β-induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM
复制标题
DOI：
10.1016/j.yexmp.2009.09.001
复制
发表时间：
2009-12-01
影响因子：
3.6
通讯作者：
Chen, Ming
中科院分区：
文献类型：
--
作者：
Chen, He;Yang, Wei-Wei;Chen, Ming
一些研究认识到癌间质成纤维细胞在癌细胞侵袭和转移中的作用。通过旁分泌信号分子TGF-β和IL-1 β，癌细胞激活基质成纤维细胞并诱导成纤维细胞活化蛋白（FAP）的表达。FAP进而影响癌细胞的增殖、侵袭和迁移。我们报告说，TGF-β和IL-1 β是诱导肌成纤维细胞分化和功能标志物，特别是α-SMA表达的重要因素。我们发现TGF-β是促进FAP α蛋白表达的主导因素。本研究还通过检测FAP对卵巢癌细胞系HO-8910 PM的增殖、迁移和侵袭能力的影响，探讨了FAP在卵巢癌细胞系HO-8910 PM中的作用。(C)2009 Elsevier Inc. All rights reserved.
Several studies recognize cancer-stromal fibroblasts' role in cancer-cell invasion and metastasis. Through paracrine signaling molecules, TGF-beta and IL-1 beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion and migration of the cancer cells. We report that TGF-beta and IL-1 beta are important factors in inducing differentiation of myofibroblasts and expression of functional markers, notably alpha-SMA. We discover that TGF-beta is the dominant factor in promoting FAP alpha protein expression. This study also examines FAP's function in vitro by assaying the proliferation, migration and invasion of ovarian cancer cell line HO-8910PM. (C) 2009 Elsevier Inc. All rights reserved.