Anti-tubulin-alpha-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations
Anti-tubulin-alpha-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations
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系统性红斑狼疮中的抗微管蛋白-α-1C自身抗体：疾病活动性和血管炎表现的新指标
DOI：
10.1007/s10067-018-4024-3
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发表时间：
2018
影响因子：
3.4
通讯作者：
Sun Xiaolin
中科院分区：
文献类型：
--
作者：
Zhao Xiaozhen;Cheng Yongjing;Gan Yuzhou;Jia Rulin;Zhu Lei;Sun Xiaolin
系统性红斑狼疮（SLE）的发病机制中涉及多种自身抗体，其中一些抗体已被广泛研究并作为疾病的生物标志物。本研究旨在检测一种新的自身抗体--抗微管蛋白-α-1C在系统性红斑狼疮（SLE）患者中的检出率，并探讨其临床意义。采用酶联免疫吸附试验（ELISA）检测了128例SLE患者、38例原发性干燥综合征（pSS）患者和106例健康对照者的抗微管蛋白-α-1C自身抗体水平，并分别检测了白色细胞（WBC）计数、红细胞沉降率（ESR）、C反应蛋白（CRP）、IgM、IgG、C3、C4、RF、ANA、dsDNA、Sm、AnuA、aCL、抗SSA、和抗SSB通过标准实验室技术测量。SLE疾病活动指数（SLEDAI）进行相应的评估。SLE患者血清中抗微管蛋白-α-1C抗体水平显著升高。抗微管蛋白-α-1C升高与SLEDAI水平升高、抗Sm抗体滴度升高和抗dsDNA抗体滴度降低相关，并与皮肤和粘膜血管炎以及轻度肾脏受累显著相关。抗微管蛋白-α-1C可能成为SLE活动性血管炎的一种新的生物标志物，并有望在未来的临床实践中得到应用。
A variety of autoantibodies has been involved in the pathogenesis of systemic lupus erythematosus (SLE), some of which are well known and applied as disease biomarkers. This study aimed to determine the prevalence of a novel autoantibody, anti-tubulin-α-1C, in patients with SLE and investigate its clinical significance. Anti-tubulin-α-1C autoantibody levels were determined by enzyme-linked immunosorbent assay (ELISA) in 128 SLE patients, 38 primary Sjögren’s syndrome (pSS) patients, and 106 healthy controls (HCs).White blood cell (WBC) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), IgM, IgG, C3, C4, RF, ANA, dsDNA, Sm, AnuA, aCL, anti-SSA, and anti-SSB were measured by standard laboratory techniques. SLE Disease Activity Index (SLEDAI) was evaluated accordingly. Anti-tubulin-α-1C antibody levels were significantly increased in SLE patients. Elevated anti-tubulin-α-1C were correlated with higher levels of SLEDAI, increased titers of anti-Sm antibody, and decreased titers of anti-dsDNA antibody and significantly associated with cutaneous and mucosal vasculitis and milder renal involvement. Anti-tubulin-α-1C may become a novel biomarker indicative of active vasculitis in SLE and could be applied in future clinical practice.