Toxicokinetics of pyrethroids in humans: Consequences for biological monitoring
Toxicokinetics of pyrethroids in humans: Consequences for biological monitoring
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DOI：
10.1007/s001289900847
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发表时间：
1999-02-01
影响因子：
2.7
通讯作者：
Idel, H
中科院分区：
文献类型：
--
作者：
Kuhn, KH;Wieseler, B;Idel, H
A simple one-compartment open model of urinary elimination kinetics is presented, and its relevance for the design of biological monitoring for pyrethroids in field studies is demonstrated. For determination of the cumulative elimination kinetics of cypermethrin and cyfluthrin, urine samples of 2 male pest control operators were collected at frequent time intervals after exposure. The total trans- to cis-chrysanthemic acid ratios were determined in urine samples of 5 operators exposed to different pyrethroids. Cyfluthrin was eliminated slightly more rapidly than cypermethrin and linear regression analysis was adequate for the estimation of half-lives. It is concluded that these findings supported the assumption that the excretion of structurally related ester pyrethroids from the human body can be described by first order kinetics.
