Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children
Polymorphisms of innate immunity genes influence disease progression in HIV-1-infected children
复制标题
DOI：
10.1097/qad.0b013e3283514350
复制
发表时间：
2012-03-27
期刊：
影响因子：
3.8
通讯作者：
De Rossi, Anita
中科院分区：
文献类型：
--
作者：
Freguja, Riccardo;Gianesin, Ketty;De Rossi, Anita
Toll样受体（TLR）和防御素（DEF）在宿主的先天免疫中起着至关重要的作用，并可能影响HIV-1疾病的进展。我们研究了TLR 9 + 1174 G>A、1635 A>G和DEF β 1 - 44 C>G、-52 G>A单核苷酸多态性对95例HIV-1感染儿童临床结局的影响。TLR 9 1635 AG基因型和TLR 9 [G;G]单倍型与快速疾病进展相关，而DEF β 1 - 44 CG基因型和DEF β 1 [G;G]单倍型与更好的临床结果相关。
Toll-like receptors (TLRs) and defensins (DEFs) play a crucial role in the host's innate immunity and may influence HIV-1 disease progression. We investigated the impact of TLR9 + 1174G>A, 1635A>G and DEF beta 1 - 44C>G, -52G>A single nucleotide polymorphisms on the clinical outcome of 95 HIV-1-infected children. The TLR9 1635AG genotype and TLR9 [G;G] haplotype were associated with rapid disease progression, whereas the DEF beta 1 -44CG genotype and DEF beta 1 [G;G] haplotype correlated with a better clinical outcome.