RELATIONSHIP OF AORTIC-WALL AND BARORECEPTOR PROPERTIES DURING DEVELOPMENT IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
RELATIONSHIP OF AORTIC-WALL AND BARORECEPTOR PROPERTIES DURING DEVELOPMENT IN NORMOTENSIVE AND SPONTANEOUSLY HYPERTENSIVE RATS
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DOI：
10.1161/01.res.43.5.728
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发表时间：
1978-01-01
影响因子：
20.1
通讯作者：
BROWN, AM
中科院分区：
文献类型：
--
作者：
ANDRESEN, MC;KRAUHS, JM;BROWN, AM
研究了 10-20 周龄正常血压 (NTR) 和自发性高血压 (SHR) 大鼠主动脉压力感受器功能与主动脉壁特性之间的关系。在切除的主动脉段中测量压力感受器放电、静压-体积和压力-半径关系。对壁厚度和受体数量进行组织学研究。计算了周向壁应力和应变以及增量弹性模量（EINC）。 100 mm Hg 下 NTR 中的 EINC 与人、狗和大鼠体内主动脉报告的值相似。第 10 周时，SHR 血压显着升高，但 SHR 和 NTR 主动脉在压力、容量、应变和 EINC 之间具有相似的关系。随后出现了差异，在 20 周时，NTR 主动脉的体积和应变更大，而在同等压力下 EINC 更小； SHR 主动脉没有变化。 SHR 相对于 NTR 主动脉的扩张性降低，并不是由于正常的退化变化，而是由于未能经历扩张性增加的阶段所致。第10周时，SHR压力感受器显示压力反应和应变反应曲线重置，早期高血压压力感受器重置可能是由于受体的主要变化。 20周时，由于NTR压力感受器的应变敏感性降低，NTR和SHR压力感受器的应变响应曲线的顺序颠倒。发育过程中 NTR 压力感受器的重置可能作为发育过程中血压控制的机制具有重要意义。
The relationship between aortic baroreceptor function and aortic wall properties in normotensive (NTR) and spontaneously hypertensive (SHR) rats 10-20 wk old was studied. Baroreceptor discharge, static pressure-volume and pressure-radius relationships were measured in excised aortic segments. Histological studies of wall thickness and receptor numbers were made. Circumferential wall stress and strain and the incremental elastic modulus (EINC) were calculated. EINC in NTR at 100 mm Hg were similar to values reported for in vivo human, dog and rat aortas. At 10 wk, SHR had significantly elevated blood pressure, but SHR and NTR aortas had similar relationships among pressures, volume, strain and EINC. Differences subsequently arose and, at 20 wk, NTR aortas had larger volumes and strains and smaller EINC at equivalent pressures; SHR aortas were unchanged. The reduced distensibility of SHR relative to NTR aortas, rather than being due to retrogressive changes from normal, appeared to result from a failure to pass through a phase of increased distensibility. At 10 wk, SHR baroreceptors showed resetting in pressure-response and strain-response curves, and early hypertensive baroreceptor resetting was probably due to primary changes in the receptors. At 20 wk, the order of the strain-response curves for NTR and SHR baroreceptors was reversed due to reduction in strain sensitivity of NTR baroreceptors. Resetting of NTR baroreceptors during development may have important implications as a mechanism of blood pressure control in development.