Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry.
Traffic-related exposures and biomarkers of systemic inflammation, endothelial activation and oxidative stress: a panel study in the US trucking industry.
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DOI：
10.1186/1476-069x-12-105
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发表时间：
2013-12-07
期刊：
影响因子：
--
通讯作者：
Laden F
中科院分区：
文献类型：
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作者：
Neophytou AM;Hart JE;Cavallari JM;Smith TJ;Dockery DW;Coull BA;Garshick E;Laden F
实验证据表明，吸入汽车尾气中的颗粒对炎症、内皮活化和氧化应激具有系统性影响。在本研究中，我们评估了卡车运输行业工人中短期暴露与炎症内皮激活和氧化应激生物标志物水平的关系。在轮班前和轮班后、每周工作开始和结束时，从 67 名不吸烟的美国卡车运输业男性工人身上采集了血液和尿液样本。同时测量微环境中元素碳和有机碳 (EC & OC) 以及细颗粒物 (PM2.5) 的浓度，并结合时间活动模式，可以计算个体暴露情况。使用重复测量的线性混合效应模型评估每日、第一天和最后一天的平均暴露水平与重复测量细胞间和血管细胞粘附分子-1 (ICAM-1 & VCAM-1)、白细胞介素 6 (IL-6) 和 C 反应蛋白 (CRP) 血液水平以及尿 8-羟基-2'-脱氧鸟苷 (8-OHdG) 之间的关联。每个 IQR 暴露量中，第一天和最后一天的平均 PM2.5 和 8-OHdG（增加 21%，95% CI：2, 42%）与第一天和最后一天的平均 OC 和 IL-6 水平（增加 18%，95% CI：1, 37%）之间存在统计显着相关性。没有与 EC 相关的显着发现或提示急性交叉转移效应的关联。我们的研究结果表明，每周平均暴露的 PM2.5 与氧化应激标志物和 OC 与 IL-6 水平之间存在关联。
Experimental evidence suggests that inhaled particles from vehicle exhaust have systemic effects on inflammation, endothelial activation and oxidative stress. In the present study we assess the relationships of short-term exposures with inflammatory endothelial activation and oxidative stress biomarker levels in a population of trucking industry workers. Blood and urine samples were collected pre and post-shift, at the beginning and end of a workweek from 67 male non-smoking US trucking industry workers. Concurrent measurements of microenvironment concentrations of elemental and organic carbon (EC & OC), and fine particulate matter (PM2.5) combined with time activity patterns allowed for calculation of individual exposures. Associations between daily and first and last-day average levels of exposures and repeated measures of intercellular and vascular cell adhesion molecule-1 (ICAM-1 & VCAM-1), interleukin 6 (IL-6) and C-reactive protein (CRP) blood levels and urinary 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) were assessed using linear mixed effects models for repeated measures. There was a statistically significant association between first and last-day average PM2.5 and 8-OHdG (21% increase, 95% CI: 2, 42%) and first and last-day average OC and IL-6 levels (18% increase 95% CI: 1, 37%) per IQR in exposure. There were no significant findings associated with EC or associations suggesting acute cross-shift effects. Our findings suggest associations between weekly average exposures of PM2.5 on markers of oxidative stress and OC on IL-6 levels.